Chemical Property of 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride
Chemical Property:
- Appearance/Colour:white solid
- Melting Point:220.5°; mp 219.3° (Shirotani)
- Boiling Point:506.2 °C at 760 mmHg
- Flash Point:259.9 °C
- PSA：70.68000
- LogP:4.17030
- Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
- Solubility.:H2O: >200 mg/mL
- Water Solubility.:Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:327.0808257
- Heavy Atom Count:21
- Complexity:421
- Purity/Quality:
-
99% *data from raw suppliers
HA1077 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
22
- Safety Statements:
36-60
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.[Cl-]
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Description
Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed
for the treatment of cerebral vasospasm following subarachnoid hemorrhage
(SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase
C. In contrast to other calcium channel blockers, which regulate the influx of calcium
ions through the cell membrane but not involved in the intracellular regulatory
mechanism of the calcium, fasudil was suggested to have an intracellular mode of
action in relaxing vascular smooth muscle. In patients with neurological deficits due to
vasospasm, fasudil decreased the occurrence of angiographic severe and
symptomatic vasospasm and cerebral infarction without decreasing systemic blood
pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of
cerebral vascular diseases and angina pectoris.
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Uses
Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration. vasodilator, potent Rho-kinase inhibitor
