4,6-DIFLUOROINDOLE-2-ETHYL CARBOXYLATE

Base Information

• Chemical Name: 4,6-DIFLUOROINDOLE-2-ETHYL CARBOXYLATE
• CAS No.: 870536-93-9
• Molecular Formula: C11H9F2NO2
• Molecular Weight: 225.19100
• Hs Code.: 2933990090
• Mol file: 870536-93-9.mol

Synonyms:4-chloro-6-chloro-3-carbethoxyquinoline;ethyl 4,6-difluoroindole-2-carboxylate;4,6-Difluoroindole-2-ethyl carboxylate;ethyl-4,6-dichloroquinoline-3-carboxylate;4,6-dichloro-quinoline-3-carboxylic acid ethyl ester;

Chemical Property of 4,6-DIFLUOROINDOLE-2-ETHYL CARBOXYLATE

Chemical Property:

• PSA: 42.09000
• LogP: 2.62280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4,6-Difluoro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DIFLUOROINDOLE-2-ETHYL CARBOXYLATE

There total 5 articles about 4,6-DIFLUOROINDOLE-2-ETHYL CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-(3,5-difluorophenylhydrazino)propionate (1003005-38-6) → ethyl 4,6-difluoro-1H-indole-2-carboxylate (870536-93-9)

Guidance literature:

With polyphosphoric acid; In toluene; at 70 - 100 ℃; for 2h; Temperature; Large scale;

Reference yield: 62.0%

2-oxo-propionic acid ethyl ester (617-35-6) + (3,5-difluorophenyl)hydrazine hydrochloride (502496-27-7) → ethyl 4,6-difluoro-1H-indole-2-carboxylate (870536-93-9)

Guidance literature:

2-oxo-propionic acid ethyl ester; (3,5-difluorophenyl)hydrazine hydrochloride; With triethylamine; In benzene; at 0 - 20 ℃; for 6h; Heating / reflux;

With PPA; In toluene; Heating / reflux;

Reference yield: 30.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 3,5-difluoroaniline (372-39-4) → ethyl 4,6-difluoro-1H-indole-2-carboxylate (870536-93-9)

Guidance literature:

With oxygen; palladium diacetate; acetic acid; In dimethyl sulfoxide; at 80 ℃; for 36h; under 760.051 Torr; regioselective reaction; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.joc.8b02180

upstream raw materials:

ethyl 2-(3,5-difluorophenylhydrazino)propionate

2-oxo-propionic acid ethyl ester

(3,5-difluorophenyl)hydrazine hydrochloride

3,5-difluoroaniline

Downstream raw materials:

4,6-difluoro-1H-indole-2-carboxylic acid