ethyl 2-(3,5-difluorophenylhydrazino)propionate

Base Information

• Chemical Name: ethyl 2-(3,5-difluorophenylhydrazino)propionate
• CAS No.: 1003005-38-6
• Molecular Formula: C₁₁H₁₂F₂N₂O₂
• Molecular Weight: 242.225
• Mol file: 1003005-38-6.mol

Synonyms:ethyl 2-(3,5-difluorophenylhydrazino)propionate

Chemical Property of ethyl 2-(3,5-difluorophenylhydrazino)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(3,5-difluorophenylhydrazino)propionate

There total 2 articles about ethyl 2-(3,5-difluorophenylhydrazino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) + (3,5-difluorophenyl)hydrazine hydrochloride (502496-27-7) → ethyl 2-(3,5-difluorophenylhydrazino)propionate (1003005-38-6)

Guidance literature:

In methanol; for 1h; Heating / reflux;

Reference yield:

2-acetylpropanoic acid ethyl ester (609-14-3) + 3,5-difluoroaniline (372-39-4) → ethyl 2-(3,5-difluorophenylhydrazino)propionate (1003005-38-6)

Guidance literature:

3,5-difluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.333333h;

2-acetylpropanoic acid ethyl ester; With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.166667h;

In ethanol; water; at 0 - 40 ℃; for 0.25h;

DOI:10.1021/acsmedchemlett.5b00482

Reference yield: 100.0%

ethyl 2-(3,5-difluorophenylhydrazino)propionate (1003005-38-6) → ethyl 4,6-difluoro-1H-indole-2-carboxylate (870536-93-9)

Guidance literature:

With polyphosphoric acid; In toluene; at 70 - 100 ℃; for 2h; Temperature; Large scale;

upstream raw materials:

2-oxo-propionic acid ethyl ester

(3,5-difluorophenyl)hydrazine hydrochloride

2-acetylpropanoic acid ethyl ester

3,5-difluoroaniline

Downstream raw materials:

ethyl 4,6-difluoro-1H-indole-2-carboxylate

Refernces

• 1、 -. "Indole derivatives". Page/Page column 11. . Retrieved 2008/06/13.