1-(1-BENZYL-PYRROLIDIN-3-YL)-ETHANON

Base Information

• Chemical Name: 1-(1-BENZYL-PYRROLIDIN-3-YL)-ETHANON
• CAS No.: 87088-73-1
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• Hs Code.: 2933990090
• Mol file: 87088-73-1.mol

Synonyms:3-acetyl-1-benzyl-pyrrolidine;3-Acetyl-1-benzyl-pyrrolidin;

Chemical Property of 1-(1-BENZYL-PYRROLIDIN-3-YL)-ETHANON

Chemical Property:

• Boiling Point: 98-99 °C(Press: 0.15 Torr)
• PKA: 8.43±0.40(Predicted)
• PSA: 20.31000
• Density: 1.073±0.06 g/cm3(Predicted)
• LogP: 2.03540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(1-benzylpyrrolidin-3-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-BENZYL-PYRROLIDIN-3-YL)-ETHANON

There total 1 articles about 1-(1-BENZYL-PYRROLIDIN-3-YL)-ETHANON which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(2-hydroxy-2-methyl)but-3-enyl-N-benzylamine (69917-78-8) → 3-acetyl-1-benzylpyrrolidine (87088-73-1)

Guidance literature:

With camphor-10-sulfonic acid; In benzene; for 10h; Heating;

DOI:10.1021/ja00360a013

Reference yield: 67.0%

3-acetyl-1-benzylpyrrolidine (87088-73-1) + t-butoxycarbonylhydrazine (870-46-2) + di-tert-butyl dicarbonate (24424-99-5) → N-[1-(1-benzyl-pyrrolidin-3-yl)-ethyl]-N'-tert-butoxycarbonyl-hydrazinecarboxylic acid tert-butyl ester (861391-51-7)

Guidance literature:

3-acetyl-1-benzylpyrrolidine; t-butoxycarbonylhydrazine; With acetic acid; In methanol; at 20 ℃;

With sodium cyanoborohydride; toluene-4-sulfonic acid; In methanol; at 0 - 20 ℃; for 4h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 47.0%

3-acetyl-1-benzylpyrrolidine (87088-73-1) + trimethyl(difluoromethyl)silane (65864-64-4) → 2-(1-benzylpyrrolidin-3-yl)-1,1-difluoropropan-2-ol

Guidance literature:

3-acetyl-1-benzylpyrrolidine; trimethyl(difluoromethyl)silane; With N,N,N,N,N,N-hexamethylphosphoric triamide; cesium fluoride; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2016.01.032

upstream raw materials:

formaldehyd

N-(2-hydroxy-2-methyl)but-3-enyl-N-benzylamine

Downstream raw materials:

1-benzyl-3-[(1'-hydroxy)ethyl]pyrrolidine

N-[1-(1-benzyl-pyrrolidin-3-yl)-ethyl]-N'-tert-butoxycarbonyl-hydrazinecarboxylic acid tert-butyl ester

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