Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-

Base Information

Chemical Name:Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-
CAS No.:68427-04-3
Molecular Formula:C25H30Cl2N4O4
Molecular Weight:521.444
Hs Code.:
DSSTox Substance ID:DTXSID20218544

Synonyms:1-((Phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)glycinamide;Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-;68427-04-3;C25H30Cl2N4O4;DTXSID20218544;C25-H30-Cl2-N4-O4;LS-72212

Suppliers and Price of Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-

Chemical Property:

Vapor Pressure:3.06E-21mmHg at 25°C
Boiling Point:731.2°Cat760mmHg
Flash Point:396°C
Density:1.339g/cm³
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:520.1644108
Heavy Atom Count:35
Complexity:678

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NC(=O)CNC3=CC=C(C=C3)N(CCCl)CCCl
Isomeric SMILES:C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NC(=O)CNC3=CC=C(C=C3)N(CCCl)CCCl

Technology Process of Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)-

There total 3 articles about Glycinamide, 1-((phenylmethoxy)carbonyl)-L-prolyl-N-(4-(bis(2-chloroethyl)amino)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2067-58-5
4-amino-N,N-bis(2-chloroethyl)aniline

: 2766-18-9
N-carbobenzoxyprolylglycine

: 68427-04-3
(S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: N-carbobenzoxyprolylglycine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.166667h;

4-amino-N,N-bis(2-chloroethyl)aniline;
DOI:10.1016/j.ejps.2004.09.006

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 68427-04-3
(S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / H₂O

2: 75 percent / N-methylmorpholine; isobutylchloroformiate / tetrahydrofuran / 0.17 h / -10 °C

With 4-methyl-morpholine; potassium carbonate; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1016/j.ejps.2004.09.006

Reference yield:

: 2578-57-6
N-prolylglycine

: 68427-04-3
(S)-2-[({4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / H₂O

2: 75 percent / N-methylmorpholine; isobutylchloroformiate / tetrahydrofuran / 0.17 h / -10 °C

With 4-methyl-morpholine; potassium carbonate; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1016/j.ejps.2004.09.006