1H-1-Benzazepine-1-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-tetrazol-5-ylamino]-2,3,4,5- tetrahydro-7-methyl-8-(trifluoromethyl)-, 1,1-dimethylethyl ester, (5S)-

Base Information

• Chemical Name: 1H-1-Benzazepine-1-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-tetrazol-5-ylamino]-2,3,4,5- tetrahydro-7-methyl-8-(trifluoromethyl)-, 1,1-dimethylethyl ester, (5S)-
• CAS No.: 872624-65-2
• Molecular Formula: C27H27F9N6O2
• Molecular Weight: 638.536

Synonyms:

Chemical Property of 1H-1-Benzazepine-1-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-tetrazol-5-ylamino]-2,3,4,5- tetrahydro-7-methyl-8-(trifluoromethyl)-, 1,1-dimethylethyl ester, (5S)-

Chemical Property:

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Technology Process of 1H-1-Benzazepine-1-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-tetrazol-5-ylamino]-2,3,4,5- tetrahydro-7-methyl-8-(trifluoromethyl)-, 1,1-dimethylethyl ester, (5S)-

There total 1 articles about 1H-1-Benzazepine-1-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-tetrazol-5-ylamino]-2,3,4,5- tetrahydro-7-methyl-8-(trifluoromethyl)-, 1,1-dimethylethyl ester, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)cyanoamino]-7-methyl-8-trifluoromethyl-2,3,4.,5-tetrahydrobenzo[b]azepine-1-carboxylate (872624-64-1) → (S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)-(2H-tetrazol-5-yl)amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate (872624-65-2)

Guidance literature:

With sodium azide; triethylamine hydrochloride; In toluene; for 12h; Heating / reflux;

Reference yield: 95.0%

methanol (67-56-1) + (S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)-(2H-tetrazol-5-yl)amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate (872624-65-2) → (S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)-(2-methyl-2H-tetrazol-5-yl)amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 - 20 ℃; for 12h;

Reference yield: 26.0%

(S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)-(2H-tetrazol-5-yl)amino]-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate (872624-65-2) + 2-bromoethanol (540-51-2) → (S)-5-{(3,5-bis-trifluoromethyl-benzyl)-[2-(2-hydroxy-ethyl)-2H-tetrazol-5-yl]-amino}-7-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylic acid tert-butyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

(S)-tert-butyl 5-[(3,5-bistrifluoromethylbenzyl)cyanoamino]-7-methyl-8-trifluoromethyl-2,3,4.,5-tetrahydrobenzo[b]azepine-1-carboxylate

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