3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-

Base Information

Chemical Name:3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-
CAS No.:873443-68-6
Molecular Formula:C17H16ClN3O
Molecular Weight:313.787
Hs Code.:
DSSTox Substance ID:DTXSID30470313
Wikidata:Q82298383

Synonyms:873443-68-6;2-Chloro-6-morpholino-4-(o-tolyl)nicotinonitrile;3-PYRIDINECARBONITRILE, 2-CHLORO-4-(2-METHYLPHENYL)-6-(4-MORPHOLINYL)-;SCHEMBL1399409;DTXSID30470313;AC7042;MFCD30549006;AKOS030542744;SY233463;CS-0457585;A916909;2-chloro-4-(2-methylphenyl)-6-morpholin-4-ylpyridine-3-carbonitrile

Suppliers and Price of 3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:313.0981898
Heavy Atom Count:22
Complexity:417

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1C2=CC(=NC(=C2C#N)Cl)N3CCOCC3

Technology Process of 3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)-

There total 5 articles about 3-Pyridinecarbonitrile, 2-chloro-4-(2-methylphenyl)-6-(4-morpholinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

: 110-91-8,99108-56-2
morpholine

: 873443-66-4
3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine

: 873443-68-6
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine

Guidance literature:: In methanol; at 18 - 25 ℃; for 18.75h;

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 873443-68-6
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine

: C₁₇H₁₆ClN₃O

Guidance literature:: Multi-step reaction with 4 steps

1: morpholine / isopropyl alcohol / 1 h / 20 - 33 °C

2: triethylamine / methanol / 66.02 h / 25 °C / Reflux

3: trichlorophosphate / 10 h / 135 °C

4: methanol / 18.75 h / 18 - 25 °C

With morpholine; triethylamine; trichlorophosphate; In methanol; isopropyl alcohol;
DOI:10.1021/op060128m

Reference yield:

: 5'-cyano-1',2',3',4'-tetrahydro-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium inner salt

: 873443-68-6
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine

: C₁₇H₁₆ClN₃O

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 10 h / 135 °C

2: methanol / 18.75 h / 18 - 25 °C

With trichlorophosphate; In methanol;
DOI:10.1021/op060128m