2-hydroxy-3,5,6-trimethyl-1H-pyridin-4-one

Base Information

• Chemical Name: 2-hydroxy-3,5,6-trimethyl-1H-pyridin-4-one
• CAS No.: 109371-16-6
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.181
• Hs Code.: 2933399090
• Mol file: 109371-16-6.mol

Synonyms:2,3,5-Trimethyl-4,6-dihydroxypyridine

Chemical Property of 2-hydroxy-3,5,6-trimethyl-1H-pyridin-4-one

Chemical Property:

• Vapor Pressure: 0.00127mmHg at 25°C
• Boiling Point: 265.3°Cat760mmHg
• Flash Point: 114.3°C
• PSA: 53.35000
• Density: 1.138g/cm³
• LogP: 1.41800

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-3,5,6-trimethyl-1H-pyridin-4-one

There total 1 articles about 2-hydroxy-3,5,6-trimethyl-1H-pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 3-amino-2-methyl-2-butenoate (54393-21-4) + Diethyl methylmalonate (609-08-5) → 4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone (109371-16-6)

Guidance literature:

With sodium ethanolate; In toluene; for 24h; Heating;

Reference yield: 95.0%

4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone (109371-16-6) → 2,4-dichloro-3,5,6-trimethylpyridine (109371-17-7)

Guidance literature:

With trichlorophosphate; at 150 ℃; for 4h;

Reference yield:

4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone (109371-16-6) → 2,3,5-trimethyl-pyridine (695-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / phosphoryl chloride / 4 h / 150 °C

2: 83 percent / hydrogen, conc. NH₃ / 10percent Pd/C / ethanol / 3 h / 2250.2 Torr / further reagent zinc powder, H₂SO₄

With ammonium hydroxide; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol;

upstream raw materials:

ethyl 3-amino-2-methyl-2-butenoate

Diethyl methylmalonate

Downstream raw materials:

2,4-dichloro-3,5,6-trimethylpyridine

4-bromo-2-methoxy-3,5,6-trimethylpyridine

2,3,5-trimethyl-pyridine

4-chloro-2,3,5-trimethylpyridine

Refernces

• 1、 Mittelbach,Schmidt,Uray,Junek,Lamm,Ankner,Br?ndstr?m,Simonsson. "Synthesis of 4-methoxy-2,3,5-trimethylpyridine: a specific building block for compounds with gastric-acid inhibiting activity.". . p. 524 - 529. Retrieved 2007/10/02.