(Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester

Base Information

• Chemical Name: (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester
• CAS No.: 54393-21-4
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Mol file: 54393-21-4.mol

Synonyms:2-(1-amino-3-methylbutyl)aniline;

Chemical Property of (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester

Chemical Property:

• PSA: 52.32000
• LogP: 1.50240
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(Z)-3-Amino-2-methyl-2-butenoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester

There total 2 articles about (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-acetylpropanoic acid ethyl ester (609-14-3) → ethyl 3-amino-2-methyl-2-butenoate (54393-21-4)

Guidance literature:

With ammonia; 1.) -> 80 deg C, 4 h, 2.) 80 deg C, 14 h;

Reference yield:

ethyl 3-aminobut-2-enoate (626-34-6) + methyl iodide (74-88-4) → ethyl (Z)-3-(methylamino)-2-butenoate (21759-70-6) + ethyl 3-amino-2-methyl-2-butenoate (54393-21-4)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; Product distribution; further reactants, further temps., further time;

Reference yield: 76.0%

ethyl 3-amino-2-methyl-2-butenoate (54393-21-4) + Diethyl methylmalonate (609-08-5) → 4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone (109371-16-6)

Guidance literature:

With sodium ethanolate; In toluene; for 24h; Heating;

upstream raw materials:

2-acetylpropanoic acid ethyl ester

ethyl 3-aminobut-2-enoate

methyl iodide

Downstream raw materials:

(Z)-3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-2-methyl-but-2-enoic acid ethyl ester

(Z)-2-Methyl-3-(3-phenyl-ureido)-but-2-enoic acid ethyl ester

5,6-dimethyl-3-phenyl-2-thioxo-1H-pyrimidin-4-one

4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone

Refernces

• 1、 McElroy, William T.,DeShong, Philip. "Siloxane-Based Cross-Coupling of Bromopyridine Derivatives: Studies for the Synthesis of Streptonigrin and Lavendamycin". . p. 4779 - 4782. Retrieved 2007/10/03.
• 2、 Mittelbach,Schmidt,Uray,Junek,Lamm,Ankner,Br?ndstr?m,Simonsson. "Synthesis of 4-methoxy-2,3,5-trimethylpyridine: a specific building block for compounds with gastric-acid inhibiting activity.". . p. 524 - 529. Retrieved 2007/10/02.