Difluoromethylene

Base Information

• Chemical Name: Difluoromethylene
• CAS No.: 2154-59-8
• Molecular Formula: CH2F2
• Molecular Weight: 50.0078
• Mol file: 2154-59-8.mol

Synonyms:difluoromethane;difluoromethylene;HFC32

Chemical Property of Difluoromethylene

Chemical Property:

• Vapor Pressure: 13200mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: 0.929g/cm³
• LogP: 0.88290
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 49.99680632
• Heavy Atom Count: 3
• Complexity: 2.8

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: F:Flammable
• Statements: R11:
• Safety Statements: S9:; S16:; S33:

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [C](F)F

Technology Process of Difluoromethylene

There total 56 articles about Difluoromethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(trifluoro methyl) magnesiumiodide (334-98-5) → polytetrafluoroethylene (116-14-3,82785-14-6) + difluoro-methylene (2154-59-8) + trifluoromethan (75-46-7)

Guidance literature:

In diethyl ether; decomposition under reflux in ether;;

DOI:10.1039/JR9540001273

Reference yield:

1-hydro-2-chloroperfluorocyclopropene (78227-81-3) → difluoro-methylene (2154-59-8) + chloroacetylene (593-63-5) + Difluorvinylidencarben (43068-07-1)

Guidance literature:

at 900 ℃; <1E-4 mbar;

Reference yield:

3,3-Difluor-1,2-diiodcyclopropen (56830-73-0) → difluoro-methylene (2154-59-8) + diiodoacetylene (624-74-8) + Difluorvinylidencarben (43068-07-1)

Guidance literature:

at 1500 - 1700 ℃; <1E-4 mbar;

upstream raw materials:

Hexafluorobenzene

difluoromethylium

dibromodifluoromethane

iodotrifluoromethane

Downstream raw materials:

cyanogen fluoride

Dichlorodifluoromethane

polytetrafluoroethylene

C₈H₆F₄

Refernces

Electrosynthesis of ethyl α, α-difluoro-α-(phenylseleno)acetate and its photochemical synthetic application

10.1016/j.jfluchem.2003.12.015

The research focuses on the electrosynthesis of ethyl a,a-difluoro-a-(phenylseleno)acetate and its subsequent application in photochemical synthesis. The main content involves the anodic fluorination of ethyl a-fluoro-a-(phenylseleno)acetate to yield the desired difluorinated product, which is then subjected to photolysis in the presence of various olefins. This process leads to the formation of regioselective difluoromethylene adducts with good to moderate total yields. The reaction mechanism is proposed to involve an initial phenylselenyl transfer, followed by the elimination of a phenylselenyl group from the adducts to provide the final products. The experiments utilized reactants such as ethyl a-(phenylseleno)acetate, Et3N·3HF as the electrolyte, and various olefins. Analyses of the products were conducted using techniques like 1H NMR, 19F NMR, mass spectrometry (MS), and high-resolution mass spectrometry (HRMS) to confirm the structures and compositions of the synthesized compounds.