4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine

Base Information

• Chemical Name: 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine
• CAS No.: 874279-26-2
• Molecular Formula: C8H12N2O4S
• Molecular Weight: 232.25700
• Mol file: 874279-26-2.mol

Synonyms:4-(bis(methyloxy)methyl)-2-(methylsulfonyl)pyrimidine;4-(bis(methoxy)methyl)-2-methanesulfonyl-pyrimidine;4-[Bis(methyloxy)methyl]-2-(methylsulfonyl)pyrimidine;

Chemical Property of 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine

Chemical Property:

• PSA: 86.76000
• LogP: 1.25230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine

There total 5 articles about 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-dimethoxymethyl-2-methylsulfanylpyrimidine (180869-36-7) → 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine (874279-26-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

Pyruvic aldehyde dimethyl acetal (6342-56-9) → 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine (874279-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3 h / 105 °C

2.1: sodium methylate / methanol / 1 h / 0 °C

2.2: 1 h / 0 - 70 °C

2.3: 20 - 28 °C

3.1: Oxone / water; methanol / -5 - 0 °C

With Oxone; sodium methylate; In methanol; water;

Reference yield:

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one (67751-23-9,187242-85-9) → 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine (874279-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 1 h / 0 °C

1.2: 1 h / 0 - 70 °C

1.3: 20 - 28 °C

2.1: Oxone / water; methanol / -5 - 0 °C

With Oxone; sodium methylate; In methanol; water;

upstream raw materials:

4-dimethoxymethyl-2-methylsulfanylpyrimidine

Pyruvic aldehyde dimethyl acetal

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one

4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one

Downstream raw materials:

4-(dimethoxymethyl)-N-methylpyrimidin-2-amine

2-(DIMETHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE

2-(methylamino)pyrimidine-4-carbaldehyde