2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL

Base Information

• Chemical Name: 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL
• CAS No.: 180869-38-9
• Molecular Formula: C8H13N3O2
• Molecular Weight: 183.21
• Mol file: 180869-38-9.mol

Synonyms:2-(Methylamino)pyrimidine-4-carboxaldehyde dimethyl acetal;

Chemical Property of 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL

Chemical Property:

• Vapor Pressure: 0.00684mmHg at 25°C
• Boiling Point: 270.4°C at 760 mmHg
• Flash Point: 117.3°C
• PSA: 56.27000
• Density: 1.158g/cm³
• LogP: 0.88270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL

There total 8 articles about 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one (67751-23-9,187242-85-9) + 1-methylguanidine hydrochloride (22661-87-6,21770-81-0) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

With sodium; In ethanol; for 3h; Heating / reflux;

Reference yield: 67.0%

4-(dimethoxymethyl)pyrimidin-2-amine (165807-05-6) + methyl iodide (74-88-4) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

In acetone; at 70 ℃; Inert atmosphere;

Reference yield:

Pyruvic aldehyde dimethyl acetal (6342-56-9) + 1-methylguanidine hydrochloride (22661-87-6,21770-81-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

Pyruvic aldehyde dimethyl acetal; N,N-dimethyl-formamide dimethyl acetal; at 100 ℃; for 16h;

1-methylguanidine hydrochloride; With sodium ethanolate; In ethanol; for 24h; Heating / reflux;

upstream raw materials:

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one

1-methylguanidine hydrochloride

Pyruvic aldehyde dimethyl acetal

4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one

Downstream raw materials:

2-(methylamino)pyrimidine-4-carbaldehyde

Refernces

• 1、 -. "NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". . . Retrieved 2015/07/15.
• 2、 -. "INDOLE OR BENZIMIDAZOLE DERIVATIVES FOR MODULATING IκB KINASE". Page/Page column 18-19. . Retrieved 2010/11/30.