4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine

Base Information

• Chemical Name: 4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine
• CAS No.: 180869-38-9
• Molecular Formula: C8H13N3O2
• Molecular Weight: 183.21
• DSSTox Substance ID: DTXSID50591211
• Wikidata: Q82484934
• Mol file: 180869-38-9.mol

Synonyms:4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine;180869-38-9;2-(Methylamino)pyrimidine-4-carboxaldehyde dimethyl acetal;2-Pyrimidinamine, 4-(dimethoxymethyl)-N-methyl-;(4-dimethoxymethyl-pyrimidin-2-yl)-methyl-amine;2-methylaminopyrimidine-4-carboxaldehyde dimethylacetal;SCHEMBL1800915;DTXSID50591211;GVTZVNRRGNBOJF-UHFFFAOYSA-N;MFCD10566061;AKOS006302683;DS-3049;SB57341;DB-303591;CS-0151234;H11486;2-methylaminopyrimidine-4-carboxaldehyde dimethyl acetal

Chemical Property of 4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine

Chemical Property:

• Vapor Pressure: 0.00684mmHg at 25°C
• Boiling Point: 270.4°C at 760 mmHg
• Flash Point: 117.3°C
• PSA: 56.27000
• Density: 1.158g/cm³
• LogP: 0.88270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 183.100776666
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC=CC(=N1)C(OC)OC

Technology Process of 4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine

There total 8 articles about 4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one (67751-23-9,187242-85-9) + 1-methylguanidine hydrochloride (22661-87-6,21770-81-0) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

With sodium; In ethanol; for 3h; Heating / reflux;

Reference yield: 67.0%

4-(dimethoxymethyl)pyrimidin-2-amine (165807-05-6) + methyl iodide (74-88-4) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

In acetone; at 70 ℃; Inert atmosphere;

Reference yield:

Pyruvic aldehyde dimethyl acetal (6342-56-9) + 1-methylguanidine hydrochloride (22661-87-6,21770-81-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine (180869-38-9)

Guidance literature:

Pyruvic aldehyde dimethyl acetal; N,N-dimethyl-formamide dimethyl acetal; at 100 ℃; for 16h;

1-methylguanidine hydrochloride; With sodium ethanolate; In ethanol; for 24h; Heating / reflux;

upstream raw materials:

(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one

1-methylguanidine hydrochloride

Pyruvic aldehyde dimethyl acetal

4-(dimethylamino)-1,1-dimethoxy-but-3-en-2-one

Downstream raw materials:

2-(methylamino)pyrimidine-4-carbaldehyde

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