Carbamic acid, [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]-, phenylmethyl ester
CAS No.:874360-01-7
Molecular Formula:C20H18F3NO3
Molecular Weight:377.363
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]-, phenylmethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]-, phenylmethyl ester

There total 14 articles about Carbamic acid, [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 874360-08-4
benzyl (7S,8R)-[8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]carbamate

: 874360-01-7
benzyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: With sulfuric acid; water; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 52506-21-5
8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester

: 874360-01-7
benzyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: Hunig's base

2: Na₂CO₃ / PdCl₂(dppf) / dimethylformamide

3: magnesium; methanol

4: sodium methoxide / methanol

5: lithium hydroxide / tetrahydrofuran; methanol

6: Et₃N; DPPA / toluene

7: sulfuric acid / dioxane

With methanol; lithium hydroxide; sulfuric acid; diphenyl-phosphinic acid; sodium methylate; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 6: Curtius rearrangement;
DOI:10.1016/j.bmcl.2007.03.095

Reference yield:

: 168423-42-5
methyl 8-(((trifluoromethyl)sulfonyl)oxy)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 874360-01-7
benzyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: Na₂CO₃ / PdCl₂(dppf) / dimethylformamide

2: magnesium; methanol

3: sodium methoxide / methanol

4: lithium hydroxide / tetrahydrofuran; methanol

5: Et₃N; DPPA / toluene

6: sulfuric acid / dioxane

With methanol; lithium hydroxide; sulfuric acid; diphenyl-phosphinic acid; sodium methylate; sodium carbonate; magnesium; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 5: Curtius rearrangement;
DOI:10.1016/j.bmcl.2007.03.095