Carbamic acid, [(7S,8R)-8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(7S,8R)-8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]-, phenylmethyl ester
CAS No.:874360-08-4
Molecular Formula:C22H22F3NO4
Molecular Weight:421.416
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [(7S,8R)-8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]-, phenylmethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [(7S,8R)-8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]-, phenylmethyl ester

There total 10 articles about Carbamic acid, [(7S,8R)-8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52506-21-5
8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester

: 874360-08-4
benzyl (7S,8R)-[8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

3.1: methanol; magnesium / Heating / reflux

4.1: sodium methylate / methanol / Heating / reflux

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.2: pH 1

6.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

7.1: Resolution of racemate

With methanol; lithium hydroxide; diphenyl phosphoryl azide; water; sodium methylate; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: Curtius Rearrangement;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 874360-08-4
benzyl (7S,8R)-[8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / 0.33 h / 20 - 80 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

4.1: methanol; magnesium / Heating / reflux

5.1: sodium methylate / methanol / Heating / reflux

6.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

6.2: pH 1

7.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

8.1: Resolution of racemate

With methanol; lithium hydroxide; diphenyl phosphoryl azide; water; sodium methylate; sodium hydride; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7.1: Curtius Rearrangement;

Reference yield:

: 168423-42-5
methyl 8-(((trifluoromethyl)sulfonyl)oxy)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 874360-08-4
benzyl (7S,8R)-[8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

2.1: methanol; magnesium / Heating / reflux

3.1: sodium methylate / methanol / Heating / reflux

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

4.2: pH 1

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

6.1: Resolution of racemate

With methanol; lithium hydroxide; diphenyl phosphoryl azide; water; sodium methylate; sodium carbonate; magnesium; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: Curtius Rearrangement;