3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole

Base Information

• Chemical Name: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole
• CAS No.: 16112-34-8
• Molecular Formula: C22H18 N2
• Molecular Weight: 310.398
• Mol file: 16112-34-8.mol

Synonyms:Pyrazole,1,5-diphenyl-3-p-tolyl- (8CI); NSC 150294

Chemical Property of 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole

Chemical Property:

• Vapor Pressure: 3.57E-09mmHg at 25°C
• Boiling Point: 487.3°Cat760mmHg
• Flash Point: 248.5°C
• Density: 1.08g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole

There total 26 articles about 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one (14802-30-3) + phenylhydrazine (100-63-0) → (1H)-1,5-diphenyl-3-(p-methylphenyl)pyrazole (16112-34-8)

Guidance literature:

palladium on activated charcoal; K-10 montmorillonite; In dichloromethane; at 160 ℃; for 0.5h; microwave irradiation;

DOI:10.1055/s-2007-982545

Reference yield: 92.0%

carbon monoxide (201230-82-2) + 4-tolyl iodide (624-31-7) + phenylacetylene (536-74-3) + phenylhydrazine (100-63-0) → (1H)-1,5-diphenyl-3-(p-methylphenyl)pyrazole (16112-34-8)

Guidance literature:

With triethylamine; In methanol; for 6h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/cs400077r

Reference yield: 89.0%

diethyl 2-[1,5-diphenyl-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-4-yl]malonate → (1H)-1,5-diphenyl-3-(p-methylphenyl)pyrazole (16112-34-8)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; for 6h; Heating;

DOI:10.1039/c6ob02552h

upstream raw materials:

C₂₂H₂₀N₂⁽¹⁺⁾

phenylhydrazine

1-phenyl-3-(4-methylphenyl)prop-2-yn-1-one

(E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one