8-methoxy-7H-purin-6-amine

Base Information

• Chemical Name: 8-methoxy-7H-purin-6-amine
• CAS No.: 28128-32-7
• Molecular Formula: C6H7 N5 O
• Molecular Weight: 165.1527
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50950869
• Nikkaji Number: J1.918.245B
• NSC Number: 25642
• Wikidata: Q82929050
• Mol file: 28128-32-7.mol

Synonyms:8-methoxy-7H-purin-6-amine;9H-Purin-6-amine, 8-methoxy-;SCHEMBL887193;8-Methoxy-9H-purin-6-amine;DTXSID50950869;NSC25642;NSC-25642

Chemical Property of 8-methoxy-7H-purin-6-amine

Chemical Property:

• Vapor Pressure: 0.00232mmHg at 25°C
• Boiling Point: 288.6°Cat760mmHg
• Flash Point: 128.3°C
• PSA: 84.69000
• Density: 1.76g/cm³
• LogP: -2.38870
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 165.06505986
• Heavy Atom Count: 12
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

8-METHOXY-5H-PURIN-6-AMINE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC2=NC=NC(=C2N1)N

Technology Process of 8-methoxy-7H-purin-6-amine

There total 6 articles about 8-methoxy-7H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-Benzyl-8-methoxy-3H-purin-6-ylamine (185201-10-9) → 8-methoxyadenine (28128-32-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 3h; under 760 Torr;

DOI:10.1248/cpb.44.2318

Reference yield: 72.0%

sodium methylate (124-41-4) + 8-bromoadenine (6974-78-3) → 8-methoxyadenine (28128-32-7)

Guidance literature:

In methanol; for 12h; Reflux;

DOI:10.1021/acs.jmedchem.0c00011

Reference yield:

sodium methylate (124-41-4) + 8-chloroadenine (28128-28-1) → 8-Methoxyadenin (28128-32-7)

Guidance literature:

With methanol; at 130 ℃;

DOI:10.1021/ja01557a051

upstream raw materials:

sodium methylate

8-chloroadenine

diceto-6,8 purine

6,8-dichloro-7(9)H-purine