4-Methylphenyl phosphonic dichloride

Base Information

• Chemical Name: 4-Methylphenyl phosphonic dichloride
• CAS No.: 17566-84-6
• Molecular Formula: C7H7Cl2OP
• Molecular Weight: 209.012
• NSC Number: 176342
• DSSTox Substance ID: DTXSID80306431
• Nikkaji Number: J2.064.610A
• Wikidata: Q82053532
• Mol file: 17566-84-6.mol

Synonyms:NSC176342;17566-84-6;SCHEMBL5966315;DTXSID80306431;RZEWMEXEGBBRAO-UHFFFAOYSA-N;4-methylphenyl phosphonic dichloride;p-methyl-phenyl phosphonic dichloride;NSC-176342;Phosphonic dichloride, (4-methylphenyl)-

Chemical Property of 4-Methylphenyl phosphonic dichloride

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Boiling Point: 272.6°Cat760mmHg
• Flash Point: 118.7°C
• Density: 1.34g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 207.9611572
• Heavy Atom Count: 11
• Complexity: 169

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)P(=O)(Cl)Cl

Technology Process of 4-Methylphenyl phosphonic dichloride

There total 10 articles about 4-Methylphenyl phosphonic dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tetrachloro-p-tolylphosphorane (51303-75-4) → p-tolylphosphonic dichloride (17566-84-6)

Guidance literature:

With sodium dithionite; In tetrachloromethane; at 20 ℃;

Reference yield: 90.0%

diethyl 4-methylphenylphosphonate (1754-46-7) → p-tolylphosphonic dichloride (17566-84-6)

Guidance literature:

With phosphorus pentachloride;

Reference yield:

p-tolyldichlorophosphine (1005-32-9) → p-tolylphosphonic dichloride (17566-84-6)

Guidance literature:

With phosphorus pentoxide; chlorine; at 145 ℃;

DOI:10.1021/ja01181a054

upstream raw materials:

p-tolyldichlorophosphine

tetrachloro-p-tolylphosphorane

diethyl 4-methylphenylphosphonate

para-bromotoluene

Downstream raw materials:

p-tolyl-phosphonic acid-difluoride

p-tolyl-phosphonic acid diamide

(4-methylphenyl)phosphonic acid

p-tolyl-phosphonic acid di-p-toluidide

Refernces

• 1、 Mitrasov,Anisimova,Kormachev. "Phosphorus-Containing Small Rings. IX. Reactions of Phosphorylated Methyl β-Chlorolactate Derivatives and Dialkyl 4-Chloromethylphosphonates with Salts of 2,2-Dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylic Acid". . p. 212 - 217. Retrieved 2007/10/03.
• 2、 Harger, Martin J. P.,Smith, Adrian. "N-hydroxylamines: Influence of Substituents on the Competitive Migration of Aryl and Phenyl Groups in the Lossen-like Rearrangement of their O-Methanesulphonyl Derivatives". . p. 1787 - 1792. Retrieved 2007/10/02.