1754-46-7

Basic information

• Product Name: P-TOLYL-PHOSPHONIC ACID DIETHYL ESTER
• Synonyms: CHEMPACIFIC 60155;P-TOLYL-PHOSPHONIC ACID DIETHYL ESTER;4-Methylphenylphosphonic acid diethyl ester;Diethyl 4-Methylphenyl phosphonate
• CAS NO: 1754-46-7
• Molecular Formula: C₁₁H₁₇O₃P
• Molecular Weight: 228.22
• Mol File: 1754-46-7.mol
• Article Data: 73

Chemical Properties

• Boiling Point: 298.2°C at 760 mmHg
• Flash Point: 148.1°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.00228mmHg at 25°C
• Refractive Index: 1.483
• CAS DataBase Reference: P-TOLYL-PHOSPHONIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYL-PHOSPHONIC ACID DIETHYL ESTER(1754-46-7)
• EPA Substance Registry System: P-TOLYL-PHOSPHONIC ACID DIETHYL ESTER(1754-46-7)

Safety Data

• Hazardous Substances Data: 1754-46-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 112, p. 4324, 1990 DOI: 10.1021/ja00167a032

InChI:InChI=1/C11H17O3P/c1-4-13-15(12,14-5-2)11-8-6-10(3)7-9-11/h6-9H,4-5H2,1-3H3

Upstream product

• 108-88-3 toluene 
• 64-17-5 ethanol 
• 1005-32-9 p-tolyldichlorophosphine 
• 60-29-7 diethyl ether 
• 762-04-9 Diethyl phosphonate 
• 106-38-7 para-bromotoluene 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 122-52-1 triethyl phosphite 
• 5720-05-8 4-methylphenylboronic acid 
• 17177-63-8 4-tolyl mesylate 
• 624-31-7 4-tolyl iodide 
• 93131-73-8 4-tolyl perfluorobutanesulfonate 
• 762-04-9 phosphonic acid diethyl ester 
• 106-49-0 p-toluidine 

Downstream Products

• 1142953-11-4 4-[[4-[bis(2-hydroxyethyl)amino]phenyl]diazenyl]-1-(4-phosphonobenzyl)pyridinium bromide 
• 128333-46-0 p-Tolyl-phosphonic acid monohexyl ester 
• 100926-19-0 p-tolyl-phosphonic acid anilide-methyl ester 
• 280142-25-8 (D,L)-(α-Me)Phe(4-PO3Et2)-OMe 
• 887247-21-4 2-ethoxy-3-(4-diethoxyphosphinobenzyl)pyrimidin-4-one 
• 887246-89-1 3-(4-diethoxyphosphinobenzyl)pyrimidine-2,4-dione 
• 72436-33-0 diethyl [4-(bromomethyl)phenyl]ophosphonate 
• 362477-56-3 ethyl 4-methylphenylphosphonochloridate 

Relevant articles and documents

Synthesis of arylphosphonates by arylation of phosphite anions using diaryliodonium salts

An efficient synthesis of arylphosphonates 3 is described. The method involves simple stirring of the dialkyl phosphite salts 2 with diaryliodonium salts 1 in dimethylformamide.

Microwave assisted P–C coupling reactions without directly added P-ligands

Our group introduced a green protocol for the Pd(OAc)2- or NiCl2-catalyzed P–C coupling reaction of aryl halides and various > P(O)H-compounds under MW conditions without directly added P-ligands. The reactivity of a few aryl derivatives in the Pd(OAc)2-catalyzed Hirao reaction was also studied. An induction period was observed in the reaction of bromobenzene and diphenylphosphine oxide. Finally, the less known copper(I)-promoted P–C coupling reactions were investigated experimentally. The mechanism was explored by quantum chemical calculations.

Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites

Photoinduced phosphonation of aryl triflates with trialkyl phosphites via a tandem single-electron-transfer, C-O bond cleavage and Arbuzov rearrangement process in the absence of transition-metal and external photosensitizer is reported herein. The protoc