5-CHLOROQUINOLINE

Base Information

• Chemical Name: 5-CHLOROQUINOLINE
• CAS No.: 635-27-8
• Molecular Formula: C9H6 Cl N
• Molecular Weight: 163.606
• Hs Code.: 2933499090
• Mol file: 635-27-8.mol

Synonyms:5-Chloroquinoline

Chemical Property of 5-CHLOROQUINOLINE

Chemical Property:

• Vapor Pressure: 0.0098mmHg at 25°C
• Melting Point: 28-32 °C
• Refractive Index: 1.6110 (estimate)
• Boiling Point: 273°C at 760 mmHg
• PKA: 3.88±0.12(Predicted)
• Flash Point: 145.2°C
• PSA: 12.89000
• Density: 1.27g/cm³
• LogP: 2.88820
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

5-Chloroquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Chloroquinoline (cas# 635-27-8) is a compound useful in organic synthesis.

Technology Process of 5-CHLOROQUINOLINE

There total 9 articles about 5-CHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

quinolin-5-ol (578-67-6) → 5-chloroquinoline (635-27-8)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b01379

Reference yield: 70.0%

5-Aminoquinoline (611-34-7,146614-41-7) → 5-chloroquinoline (635-27-8)

Guidance literature:

5-Aminoquinoline; With hydrogenchloride; sodium nitrite; In water; at -10 ℃; for 0.166667h;

With hydrogenchloride; copper; In water; at 85 ℃; for 2h;

DOI:10.1016/S0968-0896(02)00098-6

Reference yield: 9.0%

3-chloro-aniline (108-42-9) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5-chloroquinoline (635-27-8)

Guidance literature:

With sulfuric acid; In water; at 36 - 200 ℃; for 0.25h; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1039/c4ra00758a

upstream raw materials:

3-chloro-aniline

glycerol

dimethyl amine

5-Aminoquinoline

Downstream raw materials:

5-chloro-quinoline-8-sulfonic acid

Br^(1-)*C₁₇H₁₂ClN₂O₃⁽¹⁺⁾

Br^(1-)*C₁₈H₁₅ClNO₂⁽¹⁺⁾

5-chloro-1-phenacyl-quinolinium bromide

Refernces

• 1、 -. "INHIBITORS OF RPN11". Paragraph 0074; 0075. . Retrieved 2017/03/14.
• 2、 Khusnutdinov,Bayguzina,Aminov. "Synthesis of quinolines by iron-catalyzed reaction of anilines with propane-1,3-diol". . p. 2725 - 2727. Retrieved 2016/02/18.