4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Base Information

Chemical Name:4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one
CAS No.:87693-80-9
Molecular Formula:C19H20N2O3
Molecular Weight:324.379
Hs Code.:
DSSTox Substance ID:DTXSID00516974

Synonyms:87693-80-9;4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one;DTXSID00516974;1-(2-phenylethyl)-4-benzoyl-2-hydroxypiperazin-6-one

Suppliers and Price of 4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:442

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(N(C(=O)CN1C(=O)C2=CC=CC=C2)CCC3=CC=CC=C3)O

Technology Process of 4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one

There total 6 articles about 4-Benzoyl-6-hydroxy-1-(2-phenylethyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 152189-67-8
2-phenylethylamide of N-cyanomethylhippuric acid

: 87693-80-9
1-(2-phenylethyl)-4-benzoyl-2-hydroxypiperazin-6-one

: 152189-72-5
1-(2-phenylethyl)-4-benzoyl-2,3-dehydropiperazin-6-one

Guidance literature:: With formic acid; nickel; In water; for 2h; Heating;
DOI:10.1007/BF00531659

Reference yield:

: 98-88-4
benzoyl chloride

: 87693-80-9
1-(2-phenylethyl)-4-benzoyl-2-hydroxypiperazin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogen carbonate / H₂O / 1.5 h / 20 °C

2: 1.) dicyclohexylcarbodiimide / 1.) acetonitrile, 20 deg C, 30 min, 2.) acetonitrile, 20 deg C, 24 h

3: 23 percent / formic acid, Raney Ni / H₂O / 2 h / Heating

With formic acid; nickel; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In water;
DOI:10.1007/BF00531659

Reference yield:

: 152189-69-0
N-cyanomethylhippuric acid

: 87693-80-9
1-(2-phenylethyl)-4-benzoyl-2-hydroxypiperazin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dicyclohexylcarbodiimide / 1.) acetonitrile, 20 deg C, 30 min, 2.) acetonitrile, 20 deg C, 24 h

2: 23 percent / formic acid, Raney Ni / H₂O / 2 h / Heating

With formic acid; nickel; dicyclohexyl-carbodiimide; In water;
DOI:10.1007/BF00531659