4-Hydroxy-2,6-dimethoxybenzaldehyde

Base Information

• Chemical Name: 4-Hydroxy-2,6-dimethoxybenzaldehyde
• CAS No.: 22080-96-2
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 29125000
• Mol file: 22080-96-2.mol

Synonyms:2,6-Dimethoxy-4-hydroxybenzaldehyde;4-Formyl-3,5-dimethoxyphenol;

Chemical Property of 4-Hydroxy-2,6-dimethoxybenzaldehyde

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 5.19E-06mmHg at 25°C
• Melting Point: 225 °C (dec.)(lit.)
• Refractive Index: 1.567
• Boiling Point: 370.4 °C at 760 mmHg
• PKA: 7.04±0.23(Predicted)
• Flash Point: 152.7 °C
• PSA: 55.76000
• Density: 1.234 g/cm³
• LogP: 1.22190
• Storage Temp.: Keep Cold
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-2,6-dimethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Dimethoxy-4-hydroxybenzaldehyde (4-hydroxy-2,6-dimethoxybenzaldehyde) may be used as a test compound to investigate the bactericidal activity of benzaldehydes against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes and Salmonella enterica.

Technology Process of 4-Hydroxy-2,6-dimethoxybenzaldehyde

There total 12 articles about 4-Hydroxy-2,6-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → syringaldehyde (22080-96-2)

Guidance literature:

(3,5-dimethoxyphenoxy)triisopropylsilane; With n-butyllithium; In tetrahydrofuran;

N,N-dimethyl-formamide; In tetrahydrofuran;

With hydrogenchloride; In ethanol;

Reference yield: 23.0%

3,5-dimethoxyphenol (500-99-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-hydroxy-4,6-dimethoxybenzaldehyde (708-76-9) + syringaldehyde (22080-96-2)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 1h;

Reference yield:

3,5-dimethoxyphenol (500-99-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-hydroxy-4,6-dimethoxybenzaldehyde (708-76-9) + syringaldehyde (22080-96-2) + 2,6-diformyl-3,5-dimethoxyphenol (125666-65-1)

Guidance literature:

With trichlorophosphate; at 25 ℃; for 15h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00299a011

upstream raw materials:

3,5-dimethoxyphenol

N,N-dimethyl-formamide

hydrogenchloride

diethyl ether

Downstream raw materials:

4-ethoxy-2,6-dimethoxy-benzaldehyde

3,5-dimethoxy-4-methylphenol

1-benzyloxy-4-formyl-3,5-dimethoxybenzene

2,6-dimethoxy-4-[3-(perfluorooctyl)propyloxy]benzaldehyde