N-(5-methylpyridin-2-yl)acetamide

Base Information

• Chemical Name: N-(5-methylpyridin-2-yl)acetamide
• CAS No.: 4931-47-9
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 29333990
• European Community (EC) Number: 667-723-7
• DSSTox Substance ID: DTXSID70356026
• Nikkaji Number: J454.763B
• Wikidata: Q82135152
• Mol file: 4931-47-9.mol

Synonyms:N-(5-methylpyridin-2-yl)acetamide;4931-47-9;2-Acetamido-5-picoline;N-(5-methyl-2-pyridyl)acetamide;N-(5-METHYL-2-PYRIDINYL) ACETAMIDE;SCHEMBL423961;DTXSID70356026;ARHIRVVLQAQUCO-UHFFFAOYSA-N;AKOS003867781;SB54052;CS-0327168;FT-0629250;F81398;AI-942/25034577;J-523120

Chemical Property of N-(5-methylpyridin-2-yl)acetamide

Chemical Property:

• Vapor Pressure: 6.6E-05mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 344.4 °C at 760 mmHg
• Flash Point: 162.1 °C
• PSA: 41.99000
• Density: 1.137 g/cm³
• LogP: 1.42140
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

N-(5-Methylpyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=C1)NC(=O)C

Technology Process of N-(5-methylpyridin-2-yl)acetamide

There total 6 articles about N-(5-methylpyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-acetamido-5-methylpyridine N-oxide (65478-62-8) → N-(5-methylpyridin-2-yl)acetamide (4931-47-9)

Guidance literature:

With [Pd(dippf)Cl₂]; triethylamine; In acetonitrile; at 150 ℃; for 1h; chemoselective reaction; Microwave irradiation;

DOI:10.1055/s-0028-1083508

Reference yield: 90.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + acetic anhydride (108-24-7) → N-(5-methylpyridin-2-yl)acetamide (4931-47-9)

Guidance literature:

In toluene; at 95 ℃;

DOI:10.1080/10610278.2010.483732

Reference yield: 23.0%

3-Methylpyridine (108-99-6) + acetonitrile (75-05-8,26809-02-9) → 2-fluoro-5-methylpyridine (2369-19-9) + N-(5-methylpyridin-2-yl)acetamide (4931-47-9) + N-(2-pyridyl-3-methyl)acetamide (7463-30-1) + 2-fluoro-3-methylpyridine (2369-18-8)

Guidance literature:

With water; fluorine; at -40 - 0 ℃; for 2h;

DOI:10.1080/00397919408019063

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

acetic anhydride

3-Methylpyridine

acetonitrile

Downstream raw materials:

2-amino-5-methylpyridine-N-oxide

6-(acetylamino)pyridine-3-carboxylic acid

2-acetamido-5-methylpyridine N-oxide

2-chloro-5-methylpyridine-N-oxide