Technology Process of 1H-Pyrrole-3-carboxaldehyde,
1-[[3-(methylsulfonyl)phenyl]sulfonyl]-5-phenyl-
There total 6 articles about 1H-Pyrrole-3-carboxaldehyde,
1-[[3-(methylsulfonyl)phenyl]sulfonyl]-5-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-phenyl-1H pyrrole-3-carboxaldehyde;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
With
15-crown-5;
In
tetrahydrofuran;
for 0.5h;
3-(methylsulfonyl)benzenesulfonyl chloride;
In
tetrahydrofuran;
for 15h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
2.2: 0 - 20 °C
With
tetrapropylammonium perruthennate; sodium hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/jm300318t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / tetrahydrofuran / 20 °C / Cooling with ice
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C
4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
5.2: 0 - 20 °C
With
hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; ethanol; toluene; acetonitrile;
DOI:10.1021/jm300318t
