Technology Process of 1H-Pyrrole-3-carboxaldehyde,
1-[(2-cyanophenyl)sulfonyl]-5-(2-fluorophenyl)-
There total 5 articles about 1H-Pyrrole-3-carboxaldehyde,
1-[(2-cyanophenyl)sulfonyl]-5-(2-fluorophenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
With
15-crown-5;
In
tetrahydrofuran;
for 0.5h;
2-cyanobenzenesulfonyl chloride;
In
tetrahydrofuran;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / ethyl acetate / 18 h / 10 - 35 °C
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 36 h / 10 - 35 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.17 h / -78 °C
3.2: 1.5 h / 10 - 35 °C / Molecular sieve
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 10 - 35 °C
4.2: 0.5 h
4.3: 1 h
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; ethanol; ethyl acetate; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.17 h / -78 °C
1.2: 1.5 h / 10 - 35 °C / Molecular sieve
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 10 - 35 °C
2.2: 0.5 h
2.3: 1 h
With
sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; toluene; mineral oil;
