8-(Benzyloxy)quinoline-2-carbaldehyde

Base Information

• Chemical Name: 8-(Benzyloxy)quinoline-2-carbaldehyde
• CAS No.: 88238-73-7
• Molecular Formula: C17H13NO2
• Molecular Weight: 263.296
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID40364193
• Nikkaji Number: J3.207.802H
• Wikidata: Q82148018
• Mol file: 88238-73-7.mol

Synonyms:8-(benzyloxy)quinoline-2-carbaldehyde;88238-73-7;8-phenylmethoxyquinoline-2-carbaldehyde;8-Benzyloxy-quinoline-2-carbaldehyde;Oprea1_492455;Oprea1_805968;SCHEMBL3530872;8-benzyloxyquinoline-2-aldehyde;DTXSID40364193;MFCD00636990;8-(Benzyloxy)-2-quinolinecarbaldehyde;AKOS000320032;SB68943;CS-0206933

Chemical Property of 8-(Benzyloxy)quinoline-2-carbaldehyde

Chemical Property:

• Melting Point: 93-94 °C
• Boiling Point: 458.3±30.0 °C(Predicted)
• PKA: 1.97±0.50(Predicted)
• PSA: 39.19000
• Density: 1.235±0.06 g/cm3(Predicted)
• LogP: 3.62630
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 263.094628657
• Heavy Atom Count: 20
• Complexity: 314

Purity/Quality:

97% ^*data from raw suppliers

8-(Benzyloxy)quinoline-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC3=C2N=C(C=C3)C=O

Technology Process of 8-(Benzyloxy)quinoline-2-carbaldehyde

There total 7 articles about 8-(Benzyloxy)quinoline-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methyl-8-(benzyloxy)quinoline (93315-49-2) → 8-benzyloxyquinolin-2-yl-carboxaldehyde (88238-73-7)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 95 ℃; for 12h; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.ejmech.2011.12.037

Reference yield: 90.0%

2-formyl oxine (14510-06-6) + benzyl bromide (100-39-0) → 8-benzyloxyquinolin-2-yl-carboxaldehyde (88238-73-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.dyepig.2020.108200

Reference yield: 35.0%

2-methyl-8-quinolinol (826-81-3) + benzyl bromide (100-39-0) → 8-benzyloxyquinolin-2-yl-carboxaldehyde (88238-73-7)

Guidance literature:

With selenium(IV) oxide;

upstream raw materials:

2-methyl-8-(benzyloxy)quinoline

2-methyl-8-quinolinol

benzyl bromide

benzyl chloride

Downstream raw materials:

2-formyl oxine

1-(8-Benzyloxy-quinolin-2-yl)-9-methyl-9H-β-carboline-3-carboxylic acid ethyl ester

1-(8-Benzyloxy-quinolin-2-yl)-4-methyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid ethyl ester

quinolyl-β-carboline