2-(4-Fluorophenyl)-1-methoxyindolizine

Base Information

• Chemical Name: 2-(4-Fluorophenyl)-1-methoxyindolizine
• CAS No.: 88274-04-8
• Molecular Formula: C₁₅H₁₂FNO
• Molecular Weight: 241.265
• DSSTox Substance ID: DTXSID10539497
• Wikidata: Q82415266
• Mol file: 88274-04-8.mol

Synonyms:2-(4-Fluorophenyl)-1-methoxyindolizine;88274-04-8;DTXSID10539497

Chemical Property of 2-(4-Fluorophenyl)-1-methoxyindolizine

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 241.090292168
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2C=CC=CN2C=C1C3=CC=C(C=C3)F

Technology Process of 2-(4-Fluorophenyl)-1-methoxyindolizine

There total 1 articles about 2-(4-Fluorophenyl)-1-methoxyindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

2-(methoxymethyl)pyridine (23579-92-2) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-Fluoro-phenyl)-1-methoxy-indolizine (88274-04-8)

Guidance literature:

In acetone; for 20h; Heating;

Reference yield:

2-(4-Fluoro-phenyl)-1-methoxy-indolizine (88274-04-8) → [2-(4-Fluoro-phenyl)-1-methoxy-indolizin-3-yl]-(4-hydroxy-3-methoxy-phenyl)-methanone (88274-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 20 h / Ambient temperature

2: 30percent sodium hydroxide / methanol / 4 h / Heating

With sodium hydroxide; In methanol; 1,2-dichloro-ethane;

Reference yield:

2-(4-Fluoro-phenyl)-1-methoxy-indolizine (88274-04-8) + Toluene-4-sulfonic acid 4-chlorocarbonyl-2-methoxy-phenyl ester (88274-13-9) → Toluene-4-sulfonic acid 4-[2-(4-fluoro-phenyl)-1-methoxy-indolizine-3-carbonyl]-2-methoxy-phenyl ester

Guidance literature:

In 1,2-dichloro-ethane; for 20h; Ambient temperature;

upstream raw materials:

2-(methoxymethyl)pyridine

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

[2-(4-Fluoro-phenyl)-1-methoxy-indolizin-3-yl]-(4-hydroxy-3-methoxy-phenyl)-methanone