1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene

Base Information

• Chemical Name: 1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene
• CAS No.: 88275-72-3
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.101
• DSSTox Substance ID: DTXSID60529181
• Wikidata: Q82399403
• Mol file: 88275-72-3.mol

Synonyms:88275-72-3;1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene;SCHEMBL11145612;DTXSID60529181

Chemical Property of 1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 225.99933
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC=C1Br)CC=C

Technology Process of 1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene

There total 3 articles about 1-Bromo-2-methoxy-3-(prop-2-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-6-(2-propenyl)phenol (17269-81-7) + dimethyl sulfate (77-78-1) → 3-Brom-2-methoxy-1-(2-propenyl)benzol (88275-72-3)

Guidance literature:

With potassium carbonate; In butanone; for 4h; Heating;

DOI:10.1055/s-1989-27224

Reference yield: 88.0%

2-bromo-6-(2-propenyl)phenol (17269-81-7) + methyl iodide (74-88-4) → 3-Brom-2-methoxy-1-(2-propenyl)benzol (88275-72-3)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol;

DOI:10.1016/0040-4039(84)80039-8

Reference yield:

O-allyl-2-bromophenol (60333-75-7) → 3-Brom-2-methoxy-1-(2-propenyl)benzol (88275-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₂AlCl / hexane / 2.5 h / 20 °C

2: 85 percent / K₂CO₃ / acetone / Heating

With diethylaluminium chloride; potassium carbonate; In hexane; acetone; 1: Claisen rearrangement;

DOI:10.1039/b510653b

upstream raw materials:

2-bromo-6-(2-propenyl)phenol

dimethyl sulfate

methyl iodide

O-allyl-2-bromophenol

Downstream raw materials:

(E)-3-Bromo-2-methoxy-1-prop-1-enylbenzene

3-(3-Bromo-2-methoxy-phenyl)-propan-1-ol

3-allyl-2-methoxybenzeneboronic acid

3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester