(2-Methylphenyl)(naphthalen-2-yl)methanone

Base Information

• Chemical Name: (2-Methylphenyl)(naphthalen-2-yl)methanone
• CAS No.: 7496-04-0
• Molecular Formula: C18H14O
• Molecular Weight: 246.3032
• NSC Number: 407611
• DSSTox Substance ID: DTXSID10324729
• Nikkaji Number: J415.986A
• Wikidata: Q82084551
• Mol file: 7496-04-0.mol

Synonyms:7496-04-0;NSC 407611;NSC407611;(2-Naphthyl)(o-tolyl) ketone;SCHEMBL9857578;DTXSID10324729;AKOS012008541;NSC-407611;(2-Methylphenyl)(naphthalen-2-yl)methanone

Chemical Property of (2-Methylphenyl)(naphthalen-2-yl)methanone

Chemical Property:

• Vapor Pressure: 1.62E-05mmHg at 25°C
• Boiling Point: 365°Cat760mmHg
• Flash Point: 168.4°C
• Density: 1.13g/cm³
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 246.104465066
• Heavy Atom Count: 19
• Complexity: 322

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(=O)C2=CC3=CC=CC=C3C=C2

Technology Process of (2-Methylphenyl)(naphthalen-2-yl)methanone

There total 11 articles about (2-Methylphenyl)(naphthalen-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-(Boc)2-2-naphthamide + 2-methylphenylzinc chloride (84109-17-1) → naphthalen-2-yl(o-tolyl)methanone (7496-04-0)

Guidance literature:

N,N-(Boc)_2-2-naphthamide; With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; diethyl ether; at 23 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

2-methylphenylzinc chloride; In tetrahydrofuran; diethyl ether; at 23 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02952

Reference yield: 90.0%

2-methylphenyl bromide (95-46-5) + N-methoxy-N-methylnaphthalene-2-carboxamide (113443-62-2) → naphthalen-2-yl(o-tolyl)methanone (7496-04-0)

Guidance literature:

2-methylphenyl bromide; With magnesium; In tetrahydrofuran; at 20 - 60 ℃; for 2h;

N-methoxy-N-methylnaphthalene-2-carboxamide; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jacs.6b12293

Reference yield: 87.0%

carbon monoxide (201230-82-2) + 2-Methylphenylboronic acid (16419-60-6) + 2-naphthyldiazonium tetrafluoroborate (450-58-8) → 2-(2-methylphenyl)naphthalene (66778-24-3) + naphthalen-2-yl(o-tolyl)methanone (7496-04-0)

Guidance literature:

With palladium diacetate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 1,4-dioxane; at 100 ℃; for 5h; under 760 Torr;

DOI:10.1016/S0040-4039(02)02186-X

upstream raw materials:

ortho-tolylmagnesium bromide

2-naphthalenecarbonitrile

2-o-toluoyl-[1]naphthoic acid

naphthalene

Downstream raw materials:

2-(2-methylphenyl)naphthalene