3-Methyl-N-phenylpyridine-4-carboxamide

Base Information

Chemical Name:3-Methyl-N-phenylpyridine-4-carboxamide
CAS No.:88329-54-8
Molecular Formula:C13H12N2O
Molecular Weight:212.251
Hs Code.:
DSSTox Substance ID:DTXSID00519122
Wikidata:Q82382089

Synonyms:3-Methyl-N-phenylpyridine-4-carboxamide;88329-54-8;SCHEMBL13322124;DTXSID00519122

Suppliers and Price of 3-Methyl-N-phenylpyridine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Methyl-N-phenylpyridine-4-carboxamide

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:212.094963011
Heavy Atom Count:16
Complexity:236

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CN=C1)C(=O)NC2=CC=CC=C2

Technology Process of 3-Methyl-N-phenylpyridine-4-carboxamide

There total 5 articles about 3-Methyl-N-phenylpyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 3034-31-9
N-phenylisonicotinamide

: 75-16-1
methylmagnesium bromide

: 88329-54-8
3-methyl-N-phenyl-4-pyridinecarboxamide

Guidance literature:: With lithium manganese chloride; 1-Bromo-2-chloroethane; In tetrahydrofuran; at 25 ℃; for 24h; Schlenk technique;
DOI:10.1021/acs.orglett.7b02778

Reference yield:

: 3034-31-9
N-phenylisonicotinamide

: 74-88-4
methyl iodide

: 88329-54-8
3-methyl-N-phenyl-4-pyridinecarboxamide

: 88329-56-0
3,N-dimethylisonicotinanilide

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 0.5h, 2.) H₂O, 0.5h, 20 deg C;
DOI:10.1016/S0040-4039(00)86243-7

Reference yield:

: 39178-35-3
isonicotinoyl chloride hydrochloride

: 88329-54-8
3-methyl-N-phenyl-4-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) -78 deg C, 30 min; 25 deg C, 1.5 h

With n-butyllithium;