2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Base Information

Chemical Name:2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol
CAS No.:88467-02-1
Molecular Formula:C₂₀H₃₀N₄O₂
Molecular Weight:358.484
Hs Code.:
DSSTox Substance ID:DTXSID90524624
Wikidata:Q82391620

Synonyms:88467-02-1;DTXSID90524624;2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol;2,6-bis(diethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-oxide

Suppliers and Price of 2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:358.23687621
Heavy Atom Count:26
Complexity:384

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC1=C(C(=NC(=[N+]1[O-])CN(CC)CC)C2=CC=CC=C2)O

Technology Process of 2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol

There total 4 articles about 2,6-Bis[(diethylamino)methyl]-1-oxo-4-phenyl-1lambda~5~-pyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 660-68-4
diethyl amine hydrochloride

: 88070-45-5
4-Phenyl-5-hydroxypyrimidine 1-Oxide

: 88467-02-1
2,6-Bis(diethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: With triethylamine; In benzene; at 70 ℃; for 1h; Yield given;
DOI:10.1007/BF00506891

Reference yield:

: 3438-48-0
4-phenylpyrimidine

: 88467-02-1
2,6-Bis(diethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / 1.) 40percent HBr, H₂SO₄; 2.) sodium nitrite / H₂O / 1 h / 0 - 5 °C

2: 72 percent / sodium methoxide / methanol / 8 h / 180 °C / autoclave

3: 37 percent / m-chloroperbenzoic acid / acetone / 72 h / 20 °C

4: triethylamine / benzene / 1 h / 70 °C

With sulfuric acid; hydrogen bromide; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In methanol; water; acetone; benzene;
DOI:10.1007/BF00506891

Reference yield:

: 88070-43-3
5-Hydroxy-4-phenylpyrimidine

: 88467-02-1
2,6-Bis(diethylaminomethyl)-4-phenyl-5-hydroxypyrimidine 1-Oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / m-chloroperbenzoic acid / acetone / 72 h / 20 °C

2: triethylamine / benzene / 1 h / 70 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In acetone; benzene;
DOI:10.1007/BF00506891