4-methoxy-N-(2-methylphenyl)benzamide

Base Information

• Chemical Name: 4-methoxy-N-(2-methylphenyl)benzamide
• CAS No.: 7464-54-2
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Mol file: 7464-54-2.mol

Synonyms:

Chemical Property of 4-methoxy-N-(2-methylphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.000502mmHg at 25°C
• Boiling Point: 313.3°Cat760mmHg
• Flash Point: 143.3°C
• Density: 1.156g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxy-N-(2-methylphenyl)benzamide

There total 8 articles about 4-methoxy-N-(2-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

carbon monoxide (201230-82-2) + 4-methoxyphenylboronic acid (5720-07-0) + 2-methylphenyl diazonium tetrafluoroborate (2093-46-1) → 4-methoxy-N-(2-methylphenyl)benzamide (7464-54-2)

Guidance literature:

With ammonia; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 4.5h; under 3800 Torr;

DOI:10.1055/s-2003-42478

Reference yield: 81.0%

→ 4-methoxy-N-(2-methylphenyl)benzamide (7464-54-2)

Guidance literature:

With sodium methylate; In methanol; for 4.5h; Heating;

DOI:10.1016/0040-4039(96)01669-3

Reference yield: 76.0%

2-tolyl isocyanate (614-68-6) + 4-methoxyphenylzinc iodide (254454-47-2) → 4-methoxy-N-(2-methylphenyl)benzamide (7464-54-2)

Guidance literature:

2-tolyl isocyanate; With [Rh(OH)(cod)]2; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-methoxyphenylzinc iodide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00729

upstream raw materials:

4-methoxy-benzoyl chloride

o-toluidine

carbon monoxide

4-methoxyphenylboronic acid

Downstream raw materials:

4-methoxy-thiobenzoic acid o-toluidide

Refernces

• 1、 T?th, Balázs L.,Kovács, Szabolcs,Sályi, Gerg?,Novák, Zoltán. "Mild and efficient palladium-catalyzed direct trifluoroethylation of aromatic systems by C-H activation". supporting information. p. 1988 - 1992. Retrieved 2016/02/18.
• 2、 Correa, Arkaitz,Elmore, Simon,Bolm, Carsten. "Iron-catalyzed N-arylations of amides". experimental part. p. 3527 - 3529. Retrieved 2009/04/11.