4-METHOXYPHENYLZINC IODIDE

Base Information

• Chemical Name: 4-METHOXYPHENYLZINC IODIDE
• CAS No.: 254454-47-2
• Molecular Formula: C7H7 I O Zn
• Molecular Weight: 299.426
• Hs Code.: 29319090
• Mol file: 254454-47-2.mol

Synonyms:4-Methoxyphenylzinciodide

Chemical Property of 4-METHOXYPHENYLZINC IODIDE

Chemical Property:

• Vapor Pressure: 4.24mmHg at 25°C
• Boiling Point: 153.6°C at 760 mmHg
• Flash Point: 1 °F
• PSA: 9.23000
• Density: 1.006 g/mL at 25 °C
• LogP: 2.37860
• Storage Temp.: 2-8°C
• Sensitive.: Air & Light Sensitive
• Water Solubility.: Reacts with water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyphenylzinc iodide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-40-36/37
• Safety Statements: 16-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: It is an organometallic compounds are widely used as intermediates in organic synthesis.

Technology Process of 4-METHOXYPHENYLZINC IODIDE

There total 2 articles about 4-METHOXYPHENYLZINC IODIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

para-iodoanisole (696-62-8) + zinc (7440-66-6) → 4,4'-Dimethoxybiphenyl (2132-80-1) + methoxybenzene (100-66-3) + 4-methoxyphenylzinc iodide (254454-47-2)

Guidance literature:

With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; In acetonitrile; the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis;

DOI:10.1021/ja0289494

Reference yield:

para-iodoanisole (696-62-8) + zinc (7440-66-6) → 4-methoxyphenylzinc iodide (254454-47-2)

Guidance literature:

In further solvent(s); Sonication; (N2); solvent = 1,1,3,3-tetramethylurea; 2 equivs. of Zn powder used; 50 °C; ultrasound applied for 20 h; 18% conversion; not isolated; conversion detd. by quenching with I2;

DOI:10.1246/cl.1993.469

Reference yield: 95.0%

carbon monoxide (201230-82-2) + 4-methoxyphenylzinc iodide (254454-47-2) → bis(p-methoxyphenyl)methanone (90-96-0)

Guidance literature:

carbon monoxide; With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; at 20 ℃; for 0.166667h; under 760.051 Torr;

4-methoxyphenylzinc iodide; With ethylene dibromide; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1021/jo1025173

upstream raw materials:

para-iodoanisole

zinc

Downstream raw materials:

p-methylanizole

4,4'-Dimethoxybiphenyl

methyl 3-(4-methoxyphenyl)propionate

2-[1-(4-methoxy-phenyl)-vinyl]-1H-indole

Refernces

• 1、 Fouad, Moustafa H.,Ismailani, Uzair S.,Mair, Braeden A.,Munch, Maxime,Rotstein, Benjamin H.. "Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates". supporting information. p. 2746 - 2750. Retrieved 2020/04/16.
• 2、 Cao, Qun,Howard, Joseph L.,Wheatley, Emilie,Browne, Duncan L.. "Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling". supporting information. p. 11339 - 11343. Retrieved 2018/08/28.