1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester
CAS No.:88815-87-6
Molecular Formula:C₁₁H₂₀N₂O₃
Molecular Weight:228.291
Hs Code.:

Synonyms:tert-butyl (S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate;N-Tertiobutoxycarbonylproline-N'-methylamide;N-(tert-butyloxycarbonyl)-L-proline N'-methylamide;Boc-Pro-NHCH3;(S)-tert-butyl 2-(methylcarbamoyl)pyrrolidine-1-carboxylate;boc-L-prolyl-N'-methylamide;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 5 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：58.64000
LogP:1.46070

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 2-[(methylamino)carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 74-89-5
methylamine

: 88815-87-6,74360-79-5
tert-butyl (2S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; water; at -20 ℃; for 1h;
DOI:10.1021/ol048771l

Reference yield: 93.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 593-51-1
methylamine hydrochloride

: 88815-87-6,74360-79-5
tert-butyl (2S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 12.5h;
DOI:10.1016/j.tetlet.2015.08.078

Reference yield: 84.0%

: 88815-87-6,74360-79-5
tert-butyl (2S)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; at 0 - 20 ℃; for 12h;

upstream raw materials:

tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

methylamine

1-(tert-butoxycarbonyl)-L-proline

methylamine hydrochloride

Downstream raw materials:

DL-Pro-NHMe

L-proline methylamide

(S)-N-(tert-butoxycarbonyl)proline methyl ester

(S)-1-(1-benzyl-1H-benzo[d]imidazol-2-yl)-N-((1-((1-benzyl-1H-benzo[d]imidazol-2-yl)methyl)pyrrolidin-2-yl)methyl)-N-methylmethanamine

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