Carbamic acid, [3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]- 5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]- 5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester
CAS No.:889123-64-2
Molecular Formula:C31H36ClN5O6
Molecular Weight:610.11
Hs Code.:

Carbamic acid,
[3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]-
5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]- 5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]- 5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [3-[2-[[[2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl]amino]carbonyl]- 5-(4-morpholinyl)phenoxy]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.5%

: 889123-64-2
2-[2-(3-tert-butoxycarbonylaminopropoxy)-4-(4-morpholinyl)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

Guidance literature:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 889123-64-2
2-[2-(3-tert-butoxycarbonylaminopropoxy)-4-(4-morpholinyl)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / t-BuOK / tetrahydrofuran / -65 - 20 °C

2: 56 percent / Heating

3: 91 percent / aq. LiOH / dioxane / 60 °C

4: oxalyl chloride; DMF; pyridine / CH₂Cl₂

5: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; lithium hydroxide; oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2007.06.051

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 889123-64-2
2-[2-(3-tert-butoxycarbonylaminopropoxy)-4-(4-morpholinyl)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: H₂ / Raney Ni / tetrahydrofuran; ethyl acetate / 16 h / 20 °C / 3075.31 Torr

3: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; hydrogen; nickel; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2007.06.051