Technology Process of Pyrrolo[3,4-c]pyrrole-1,4-dione,
2,5-dihydro-3-(4-methoxyphenyl)-6-phenyl-
There total 4 articles about Pyrrolo[3,4-c]pyrrole-1,4-dione,
2,5-dihydro-3-(4-methoxyphenyl)-6-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxybenzonitrile;
With
iron(III) chloride; sodium tert-pentoxide;
In
tert-Amyl alcohol;
for 2h;
Inert atmosphere;
Reflux;
2,3-dihydro-2-oxo-5-phenyl-1H-pyrrole-4-carboxylic acid ethyl ester;
In
tert-Amyl alcohol;
at 20 - 100 ℃;
for 25h;
Inert atmosphere;
DOI:10.1007/s10895-013-1294-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / paraffin oil; water / 4 h / 100 °C
1.2: 0.5 h / 100 °C
1.3: 25 °C
2.1: potassium carbonate / acetone / 20 h / Reflux
3.1: acetic acid; ammonium acetate / 3 h / 125 °C
4.1: sodium tert-pentoxide; iron(III) chloride / tert-Amyl alcohol / 2 h / Inert atmosphere; Reflux
4.2: 25 h / 20 - 100 °C / Inert atmosphere
With
iron(III) chloride; ammonium acetate; sodium tert-pentoxide; sodium hydride; potassium carbonate; acetic acid;
In
tert-Amyl alcohol; water; acetone; paraffin oil;
DOI:10.1007/s10895-013-1294-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 20 h / Reflux
2.1: acetic acid; ammonium acetate / 3 h / 125 °C
3.1: sodium tert-pentoxide; iron(III) chloride / tert-Amyl alcohol / 2 h / Inert atmosphere; Reflux
3.2: 25 h / 20 - 100 °C / Inert atmosphere
With
iron(III) chloride; ammonium acetate; sodium tert-pentoxide; potassium carbonate; acetic acid;
In
tert-Amyl alcohol; acetone;
DOI:10.1007/s10895-013-1294-7
