(2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]pentan-2-ol

Base Information

Chemical Name:(2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]pentan-2-ol
CAS No.:16180-26-0
Molecular Formula:C26H35 N O4
Molecular Weight:425.568
Hs Code.:

Synonyms:6,14-endo-Ethenotetrahydrothebaine,7a-(1-hydroxy-1-methylbutyl)- (8CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]pentan-2-ol

Chemical Property:

Vapor Pressure:1.23E-12mmHg at 25°C
Boiling Point:543.3°Cat760mmHg
Flash Point:282.4°C
Density:1.25g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]pentan-2-ol

There total 10 articles about (2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 927-77-5
n-propylmagnesium bromide

: 15358-22-2
thevinone

: 16180-26-0
etorphine methyl ether

Guidance literature:: In tetrahydrofuran; diethyl ether; heating;
DOI:10.1248/cpb.32.1268

Reference yield: 25.0%

: 106-94-5
propyl bromide

: 15358-22-2
thevinone

: 16180-26-0
etorphine methyl ether

: 16180-14-6
(S)-1-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinan-7α-yl)-ethanol

Guidance literature:: propyl bromide; With magnesium; In diethyl ether; Inert atmosphere; Reflux;

thevinone; In diethyl ether; benzene; at 20 ℃; for 1h; stereospecific reaction; Inert atmosphere;
DOI:10.1002/jccs.201190048