N-(2-Hydroxy-2-phenylethyl)-N-methylformamide

Base Information

• Chemical Name: N-(2-Hydroxy-2-phenylethyl)-N-methylformamide
• CAS No.: 88953-55-3
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• DSSTox Substance ID: DTXSID10516203

Synonyms:88953-55-3;N-(2-Hydroxy-2-phenylethyl)-N-methylformamide;DTXSID10516203

Chemical Property of N-(2-Hydroxy-2-phenylethyl)-N-methylformamide

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(C1=CC=CC=C1)O)C=O

Technology Process of N-(2-Hydroxy-2-phenylethyl)-N-methylformamide

There total 8 articles about N-(2-Hydroxy-2-phenylethyl)-N-methylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + benzaldehyde (100-52-7) → α-phenyl-β-(N-methylformamido)ethanol (88953-55-3)

Guidance literature:

With chromium chloride; tetrakis(tetrabutylammonium)decatungstate(VI); caesium carbonate; In cyclohexane; ethyl acetate; acetonitrile; for 48h; chemoselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00096

Reference yield:

N'-tert-Butyl-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-formamidine → α-phenyl-β-(N-methylformamido)ethanol (88953-55-3)

Guidance literature:

With methanol; water; at 20 ℃; for 15h;

DOI:10.1021/ja00543a051

Reference yield:

N'-Butyl-N-(2-hydroxy-2-phenyl-ethyl)-N-methyl-formamidine → α-phenyl-β-(N-methylformamido)ethanol (88953-55-3)

Guidance literature:

With methanol; water; at 20 ℃; for 15h;

DOI:10.1021/ja00543a051

upstream raw materials:

2-dimethylamino-1-phenylethanol

2-(methylamino)-1-phenylethanol

chloral

N-methyl-2-hydroxy-2-phenylethanamide

Downstream raw materials:

2-(methylamino)-1-phenylethanol

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