Benzeneacetic acid, a-methyl-2-(2-thiazolylamino)-

Base Information

• Chemical Name: Benzeneacetic acid, a-methyl-2-(2-thiazolylamino)-
• CAS No.: 88975-49-9
• Molecular Formula: C₁₂H₁₂N₂O₂S
• Molecular Weight: 248.305
• Mol file: 88975-49-9.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-methyl-2-(2-thiazolylamino)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-methyl-2-(2-thiazolylamino)-

There total 7 articles about Benzeneacetic acid, a-methyl-2-(2-thiazolylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-ethyl cyano(2-nitrophenyl)acetate (65548-02-9) → 2-<2-(2-thiazolylamino)phenyl>propionic acid (88975-49-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

2: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

3: 89.8 percent / H₂ / 5percent Pd-C / ethanol

4: 95 percent / NH₄SCN / acetone / 1 h / Ambient temperature

5: 5.2 g / 15percent HCl / dioxane / Heating

6: 20percent HCl / aq. propan-2-ol / 2.5 h / Heating

With hydrogenchloride; hydrogen; ammonium thiocyanate; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; isopropyl alcohol; acetone;

DOI:10.1248/cpb.31.3424

Reference yield:

2-Chloronitrobenzene (88-73-3) → 2-<2-(2-thiazolylamino)phenyl>propionic acid (88975-49-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 98.6 g / NaH / dimethylformamide / 24 h / 44 - 47 °C

2: 63.4 percent / K₂CO₃ / acetone / 5 h / Heating

3: 82.9 percent / K₂CO₃ / aq. ethanol / 18 h / Heating

4: 89.8 percent / H₂ / 5percent Pd-C / ethanol

5: 95 percent / NH₄SCN / acetone / 1 h / Ambient temperature

6: 5.2 g / 15percent HCl / dioxane / Heating

7: 20percent HCl / aq. propan-2-ol / 2.5 h / Heating

With hydrogenchloride; hydrogen; ammonium thiocyanate; sodium hydride; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

DOI:10.1248/cpb.31.3424

Reference yield:

2-(2-nitrophenyl)propanenitrile (65783-00-8) → 2-<2-(2-thiazolylamino)phenyl>propionic acid (88975-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 89.8 percent / H₂ / 5percent Pd-C / ethanol

2: 95 percent / NH₄SCN / acetone / 1 h / Ambient temperature

3: 5.2 g / 15percent HCl / dioxane / Heating

4: 20percent HCl / aq. propan-2-ol / 2.5 h / Heating

With hydrogenchloride; hydrogen; ammonium thiocyanate; palladium on activated charcoal; In 1,4-dioxane; ethanol; isopropyl alcohol; acetone;

DOI:10.1248/cpb.31.3424

upstream raw materials:

Bromoacetaldehyde diethyl acetal

(+/-)-ethyl cyano(2-nitrophenyl)acetate

2-Chloronitrobenzene

2-(2-aminophenyl)propionitrile