Glycine, (2E)-2-[(5-chloro-2-methoxyphenyl)methylene]-N-[(2,4,6-trimethoxyphen yl)methyl]-b-alanyl-, monohydrochloride

Base Information

Chemical Name:Glycine, (2E)-2-[(5-chloro-2-methoxyphenyl)methylene]-N-[(2,4,6-trimethoxyphen yl)methyl]-b-alanyl-, monohydrochloride
CAS No.:889857-36-7
Molecular Formula:C23H27ClN2O7.ClH
Molecular Weight:515.391
Hs Code.:

Synonyms:

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Chemical Property of Glycine, (2E)-2-[(5-chloro-2-methoxyphenyl)methylene]-N-[(2,4,6-trimethoxyphen yl)methyl]-b-alanyl-, monohydrochloride

Chemical Property:

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Technology Process of Glycine, (2E)-2-[(5-chloro-2-methoxyphenyl)methylene]-N-[(2,4,6-trimethoxyphen yl)methyl]-b-alanyl-, monohydrochloride

There total 11 articles about Glycine, (2E)-2-[(5-chloro-2-methoxyphenyl)methylene]-N-[(2,4,6-trimethoxyphen yl)methyl]-b-alanyl-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-35-6
[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: C₂₅H₂₉ClN₂O₇*ClH

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C

2: sodium hydroxide; water / methanol / 2 h / 20 °C

With water; sodium tris(acetoxy)borohydride; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 7035-09-8
5-chloro-2-methoxybenzaldehyde

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

Guidance literature:: Multi-step reaction with 11 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; lanthanum(lll) triflate; 2,2'-iminobis[ethanol] / 60 h / 20 °C

2: triethylamine; pyridine / dichloromethane / 1 h / 0 °C

3: sodium azide / dimethyl sulfoxide / 0.5 h / 20 °C

4: triphenylphosphine / tetrahydrofuran; water / 15 h / 20 °C

5: sodium hydroxide; water / methanol / 2 h / 20 °C

6: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Cooling with ice

8: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

9: tetrahydrofuran / 0.33 h / 20 °C

10: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C

11: sodium hydroxide; water / methanol / 2 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; sodium azide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,2'-iminobis[ethanol]; triphenylphosphine; sodium hydroxide; lanthanum(lll) triflate; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 1: |Baylis-Hillman Reaction;
DOI:10.1016/j.bmc.2013.04.079