3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester
CAS No.:89226-51-7
Molecular Formula:C36H40N4O6
Molecular Weight:624.72600
Hs Code.:

Synonyms:2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-ethyl ester;

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-PyridinedicarboxylicAcid2-[4-(diphenylmethyl)-1-piperazinyl]ethylEthylEster
10mg
$ 220.00

Total 3 raw suppliers

Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester

Chemical Property:

PSA：116.93000
LogP:6.07090

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-PyridinedicarboxylicAcid2-[4-(diphenylmethyl)-1-piperazinyl]ethylEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl Ethyl Ester, is a new 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect.

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.3%

: 99-61-6
3-nitro-benzaldehyde

: 89226-49-3
2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetate

: 626-34-6,7318-00-5,41867-20-3
ethyl aminocrotonate

: 89226-51-7
2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1248/cpb.33.3787

Reference yield: 48.3%

: 89226-51-7
2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:

Reference yield:

: 10527-64-7
1-diphenylmethyl-4-(2-hydroxyethyl)piperazine

: 89226-51-7
2-(4-benzhydryl-1-piperazinyl)ethyl ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 739.8 g / 2 h / 70 - 80 °C

2: 48.3 percent / propan-2-ol / Heating

In isopropyl alcohol;
DOI:10.1248/cpb.33.3787