3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethyl methyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethyl methyl ester
• CAS No.: 89226-58-4
• Molecular Formula: C₃₅H₃₅Cl₂F₂N₃O₄
• Molecular Weight: 670.583
• Mol file: 89226-58-4.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethyl methyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

2,3-dichlorobenzylaldehyde (6334-18-5) + 2-[4-(4,4'-Difluorobenzhydryl)-1-piperazinyl]ethyl acetoacetate (90096-13-2) + methyl 3-aminocrotonate (14205-39-1) → 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (89226-58-4)

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1248/cpb.33.3787

Reference yield: 52.9%

→ 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (89226-58-4)

Guidance literature:

Reference yield:

2-(4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl)-ethanol (90096-34-7) → 2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (89226-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 - 80 °C

2: 52.9 percent / propan-2-ol / Heating

In isopropyl alcohol;

DOI:10.1248/cpb.33.3787

upstream raw materials:

2,3-dichlorobenzylaldehyde

2-[4-(4,4'-Difluorobenzhydryl)-1-piperazinyl]ethyl acetoacetate

methyl 3-aminocrotonate

2-(4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl)-ethanol