4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol

Base Information

• Chemical Name: 4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol
• CAS No.: 90096-34-7
• Molecular Formula: C₁₉H₂₂F₂N₂O
• Molecular Weight: 332.393
• DSSTox Substance ID: DTXSID001234905
• Mol file: 90096-34-7.mol

Synonyms:SCHEMBL7282615;DTXSID001234905;4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol;90096-34-7

Chemical Property of 4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 332.17001965
• Heavy Atom Count: 24
• Complexity: 338

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1CCO)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F

Technology Process of 4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol

There total 3 articles about 4-[Bis(4-fluorophenyl)methyl]-1-piperazineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(4-fluorophenyl)methyl-piperazine (27469-60-9) + 2-bromoethanol (540-51-2) → 2-(4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl)-ethanol (90096-34-7)

Guidance literature:

With potassium carbonate; In acetonitrile;

Reference yield:

1-diphenylmethyl-4-(2-hydroxyethyl)piperazine (10527-64-7) → 2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetate (89226-49-3) + 2-(4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl)-ethanol (90096-34-7)

Guidance literature:

Reference yield:

→ 2-(4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl)-ethanol (90096-34-7)

Guidance literature:

upstream raw materials:

1-diphenylmethyl-4-(2-hydroxyethyl)piperazine

1-(4-fluorophenyl)methyl-piperazine

2-bromoethanol

Downstream raw materials:

2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

2-[4-(4,4'-Difluorobenzhydryl)-1-piperazinyl]ethyl acetoacetate