Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-

Base Information

Chemical Name:Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-
CAS No.:87216-25-9
Molecular Formula:C₂₀H₁₆Cl₂N₄O₂
Molecular Weight:415.279
Hs Code.:
DSSTox Substance ID:DTXSID40236205

Synonyms:BRN 4592754;Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-;87216-25-9;C20H16Cl2N4O2;DTXSID40236205;C20-H16-Cl2-N4-O2;LS-127635

Suppliers and Price of Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-

Chemical Property:

Vapor Pressure:9.6E-19mmHg at 25°C
Boiling Point:687.3°Cat760mmHg
Flash Point:369.5°C
Density:1.49g/cm³
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:414.0650312
Heavy Atom Count:28
Complexity:723

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1=C2CN=C(C3=C(N2CC(=O)N1)C=CC(=C3)Cl)C4=CC=CC=C4Cl

Technology Process of Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-

There total 3 articles about Pyrazino(1,2-a)(1,4)benzodiazepine-4-carboxamide, 1,2,3,5-tetrahydro-9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87216-19-1
9-chloro-7-(2-chlorophenyl)-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>-benzodiazepine-4-carboxylic acid methyl ester

: 87216-25-9
9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>benzodiazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / KOH; acetic acid / methanol; H₂O / 2.5 h / Heating

2: 1.) thionyl chloride / 1.) room temp., 2 min; 2.) THF

With potassium hydroxide; thionyl chloride; acetic acid; In methanol; water;
DOI:10.1002/jhet.5570200357

Reference yield:

: 87216-18-0
7-chloro-α-(2-chloroacetylamino)-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

: 87216-25-9
9-chloro-7-(2-chlorophenyl)-N-methyl-2-oxo-1,2,3,5-tetrahydropyrazino<1,2-a><1,4>benzodiazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / triethylamine / dimethylformamide / 0.08 h / Heating

2: 79 percent / KOH; acetic acid / methanol; H₂O / 2.5 h / Heating

3: 1.) thionyl chloride / 1.) room temp., 2 min; 2.) THF

With potassium hydroxide; thionyl chloride; acetic acid; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570200357