N-glycyl-4-aminobenzoic acid ethyl ester

Base Information

• Chemical Name: N-glycyl-4-aminobenzoic acid ethyl ester
• CAS No.: 38219-44-2
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.244
• Hs Code.: 2924299090
• Mol file: 38219-44-2.mol

Synonyms:Benzoicacid, 4-[(aminoacetyl)amino]-, ethyl ester (9CI); Glycylbenzocaine; JK 23;N-Glycyl-p-aminobenzoic acid ethyl ester

Chemical Property of N-glycyl-4-aminobenzoic acid ethyl ester

Chemical Property:

• Vapor Pressure: 1.42E-07mmHg at 25°C
• Boiling Point: 429.3°Cat760mmHg
• Flash Point: 213.4°C
• PSA: 81.42000
• Density: 1.23g/cm³
• LogP: 1.53380

Purity/Quality:

99% ^*data from raw suppliers

ethyl4-(glycylamino)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-glycyl-4-aminobenzoic acid ethyl ester

There total 7 articles about N-glycyl-4-aminobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-morpholine (109-02-4) + BOC-glycine (4530-20-5) + BOC-cleavage + 3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) + 4-(2-tert-Butoxycarbonylamino-acetylamino)-benzoic acid ethyl ester (52815-80-2) + p-aminoethylbenzoate (94-09-7) → 4-glycylamino-benzoic acid ethyl ester (38219-44-2)

Guidance literature:

In dichloromethane;

Reference yield:

p-aminoethylbenzoate (94-09-7) → 4-glycylamino-benzoic acid ethyl ester (38219-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform

2: aq.-ethanolic N₂H₄

With chloroform; hydrazine;

Reference yield:

N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide (17122-79-1) → 4-glycylamino-benzoic acid ethyl ester (38219-44-2)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; Hydrogenation;

upstream raw materials:

N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide

4-[(N-formyl-glycyl)-amino]-benzoic acid

4-[(N,N-phthaloyl-glycyl)-amino]-benzoic acid ethyl ester

1,3-oxazolidine-2,5-dione

Refernces

• 1、 Kwapiszewski,Kolwas. "Synthesis of amino acid derivatives of benzocaine. II. Preparation of N-(aminoacyl)-benzocaines". . p. 257 - 260. Retrieved 2007/10/06.