6-Benzyloxymethyl-3,4-dihydro-2H-pyran

Base Information

• Chemical Name: 6-Benzyloxymethyl-3,4-dihydro-2H-pyran
• CAS No.: 89429-82-3
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• DSSTox Substance ID: DTXSID50463348
• Wikidata: Q82288208
• Mol file: 89429-82-3.mol

Synonyms:89429-82-3;6-Benzyloxymethyl-3,4-dihydro-2H-pyran;2H-Pyran, 3,4-dihydro-6-[(phenylmethoxy)methyl]-;SCHEMBL9533130;DTXSID50463348;HIHAXAWWHPHLKU-UHFFFAOYSA-N

Chemical Property of 6-Benzyloxymethyl-3,4-dihydro-2H-pyran

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 204.115029749
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC=C(OC1)COCC2=CC=CC=C2

Technology Process of 6-Benzyloxymethyl-3,4-dihydro-2H-pyran

There total 11 articles about 6-Benzyloxymethyl-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl chloride (100-44-7) + hydroxymethyl-2 dihydro-3,4 2H-pyranne (72081-17-5) → 6-benzyloxymethyl-3,4-dihydro-2H-pyran (89429-82-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1248/cpb.37.2379

Reference yield: 92.0%

benzyl bromide (100-39-0) + hydroxymethyl-2 dihydro-3,4 2H-pyranne (72081-17-5) → 6-benzyloxymethyl-3,4-dihydro-2H-pyran (89429-82-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1055/s-1997-6112

Reference yield: 91.0%

((2-(allyloxy)pent-4-enyloxy)methyl)benzene (756524-92-2) → 2-((benzyloxy)methyl)-3,4-dihydro-2H-pyran (194861-23-9) + 6-benzyloxymethyl-3,4-dihydro-2H-pyran (89429-82-3)

Guidance literature:

((2-(allyloxy)pent-4-enyloxy)methyl)benzene; With Grubbs catalyst first generation; In toluene; at 25 ℃;

With sodium hydroxide; Grubbs catalyst first generation; isopropyl alcohol; In toluene; at 110 ℃; for 2h;

DOI:10.1021/jo048937w

upstream raw materials:

benzyl chloride

hydroxymethyl-2 dihydro-3,4 2H-pyranne

benzyl bromide

3,4-dihydro-2H-pyran

Downstream raw materials:

(3R,8R,8aS)-8-Hydroxy-8a-hydroxymethyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

8,8-dimethyl-3-phenyl-2,3-dihydro-6aH-1,7,9-trioxa-3a-aza-cyclopenta[d]naphthalen-4-one

(3R,6aR,10aS)-8,8-Dimethyl-3-phenyl-tetrahydro-1,7,9-trioxa-3a-aza-cyclopenta[d]naphthalen-4-one

6-(benzyloxy)-4-[(2-methoxyethoxy)methoxy]-5-oxohexanoic acid