Technology Process of 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-YN-2-one
There total 6 articles about 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-YN-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(2,2-dichlorovinyl)-4-methoxybenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -90 - 5 ℃;
Inert atmosphere;
ethyl trifluoroacetate,;
In
tetrahydrofuran; hexane;
at -90 - 5 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.202000531
DOI:10.1021/acs.joc.0c01277
- Guidance literature:
-
With
2,6-dimethylpyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate;
In
dichloromethane;
at 20 ℃;
Sealed tube;
DOI:10.1021/jo301477s
- Guidance literature:
-
4-methoxyphenylacetylen;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
ethyl trifluoroacetate,;
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201806249
