1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol

Base Information

Chemical Name:1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol
CAS No.:89619-11-4
Molecular Formula:C11H9F3O2
Molecular Weight:230.186
Hs Code.:
NSC Number:298375
DSSTox Substance ID:DTXSID90315998

Synonyms:89619-11-4;NSC 298375;1,1,1-trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol;NSC298375;DTXSID90315998;NSC-298375

Suppliers and Price of 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol

Chemical Property:

Vapor Pressure:0.000487mmHg at 25°C
Boiling Point:300.8°Cat760mmHg
Flash Point:143°C
Density:1.31g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:230.05546401
Heavy Atom Count:16
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C#CC(C(F)(F)F)O

Technology Process of 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol

There total 5 articles about 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 89965-74-2
1,1,1-trifluoro-4-(4-methoxyphenyl)but-3-yn-2-one

: 89619-11-4
4-(4-methoxyphenyl)-1,1,1-trifluorobut-3-yn-2-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0037-1611694

Reference yield: 55.0%

: 90696-21-2
3-(4-methoxyphenyl)propynal

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 89619-11-4
4-(4-methoxyphenyl)-1,1,1-trifluorobut-3-yn-2-ol

Guidance literature:: 3-(4-methoxyphenyl)propynal; (trifluoromethyl)trimethylsilane; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere; Sealed tube;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Sealed tube;

With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Sealed tube;
DOI:10.1021/jo301477s

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 60512-57-4
1-(2,2-dibromovinyl)-4-methoxybenzene

: 89619-11-4
4-(4-methoxyphenyl)-1,1,1-trifluorobut-3-yn-2-ol

Guidance literature:: 1-(2,2-dibromovinyl)-4-methoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; hexane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2018.05.054