5,6-DIHYDROXY-7-METHOXYFLAVONE

Base Information

• Chemical Name: 5,6-DIHYDROXY-7-METHOXYFLAVONE
• CAS No.: 29550-13-8
• Molecular Formula: C16H12 O5
• Molecular Weight: 284.268
• Hs Code.: 2914509090
• Mol file: 29550-13-8.mol

Synonyms:Flavone,5,6-dihydroxy-7-methoxy- (7CI,8CI); 5,6-Dihydroxy-7-methoxyflavone;7-O-Methylbaicalein; Negletein

Chemical Property of 5,6-DIHYDROXY-7-METHOXYFLAVONE

Chemical Property:

• Vapor Pressure: 2.54E-12mmHg at 25°C
• Melting Point: 218-220oC
• Boiling Point: 541.1°Cat760mmHg
• PKA: 6.15±0.40(Predicted)
• Flash Point: 207.5°C
• PSA: 79.90000
• Density: 1.42g/cm³
• LogP: 2.87980

Purity/Quality:

≥98% ^*data from raw suppliers

Negletein ^*data from reagent suppliers

Safty Information:

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Negletein is a flavonoid used in different pharmaceutical formulations that also plays bioactive functions.

Technology Process of 5,6-DIHYDROXY-7-METHOXYFLAVONE

There total 33 articles about 5,6-DIHYDROXY-7-METHOXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-5,6-diyl diacetate (94465-55-1) → 5,6-dihydroxy-7-methoxyflavone (29550-13-8)

Guidance literature:

With hydrogenchloride; In water; acetone; for 16h; Reflux;

DOI:10.1016/j.tetlet.2016.02.093

Reference yield: 96.0%

mosloflavone (740-33-0) → 5,6-dihydroxy-7-methoxyflavone (29550-13-8)

Guidance literature:

With water; hydrogen bromide; acetic acid; for 3h; Reflux;

DOI:10.1016/j.tet.2009.12.021

Reference yield: 85.0%

5,6,7-trimethoxyflavone (973-67-1) → 5,6-dihydroxy-7-methoxyflavone (29550-13-8)

Guidance literature:

With water; hydrogen bromide; Aliquat 336; at 105 ℃; for 7h; Catalytic behavior;

DOI:10.1080/00397911.2013.772201

upstream raw materials:

8-amino-5-hydroxy-7-methoxy-2-phenyl-chromen-4-one

6-hydroxy-5,7-dimethoxyflavone

hydrogenchloride

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Downstream raw materials:

7-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-5,6-diyl diacetate

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Refernces

• 1、 Hemantha, Hosahalli P.,Ramanujam, Rajendran,Majeed, Muhammed,Nagabhushanam, Kalyanam. "An unambiguous and practical synthesis of Oroxylin A: a commonly misidentified flavone". . p. 1413 - 1420. Retrieved 2019/08/22.
• 2、 -. "PROCESS FOR SYNTHESIS OF OROXYLIN A". Page/Page column 7-9. . Retrieved 2020/03/02.