2-(2,5-Dioxopyrrolidin-1-yl)acetic acid

Base Information

• Chemical Name: 2-(2,5-Dioxopyrrolidin-1-yl)acetic acid
• CAS No.: 5626-41-5
• Molecular Formula: C6H7 N O4
• Molecular Weight: 157.12
• Hs Code.: 2925190090
• European Community (EC) Number: 837-637-6
• NSC Number: 58199
• DSSTox Substance ID: DTXSID00204809
• Nikkaji Number: J1.943.796E
• Wikidata: Q83078268
• Mol file: 5626-41-5.mol

Synonyms:N-succinylglycine

Chemical Property of 2-(2,5-Dioxopyrrolidin-1-yl)acetic acid

Chemical Property:

• Vapor Pressure: 1.27E-09mmHg at 25°C
• Boiling Point: 457°Cat760mmHg
• Flash Point: 230.2°C
• PSA: 74.68000
• Density: 1.496g/cm³
• LogP: -0.84210
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 157.03750770
• Heavy Atom Count: 11
• Complexity: 207

Purity/Quality:

98%min ^*data from raw suppliers

(2,5-Dioxopyrrolidin-1-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N(C1=O)CC(=O)O

Technology Process of 2-(2,5-Dioxopyrrolidin-1-yl)acetic acid

There total 4 articles about 2-(2,5-Dioxopyrrolidin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

succinic acid anhydride (108-30-5) + glycine (56-40-6,18875-39-3,25718-94-9) → 2-(2,5-dioxopyrrolidin-1-yl)acetic acid (5626-41-5)

Guidance literature:

In toluene; Reflux;

DOI:10.1016/j.ejmech.2009.07.006

Reference yield: 62.0%

succinic acid (110-15-6) + glycine (56-40-6,18875-39-3,25718-94-9) → 2-(2,5-dioxopyrrolidin-1-yl)acetic acid (5626-41-5)

Guidance literature:

In water; at 180 ℃;

DOI:10.1016/j.bmcl.2011.07.118

Reference yield:

C13H13NO4 (92029-72-6) → 2-(2,5-dioxopyrrolidin-1-yl)acetic acid (5626-41-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 3h;

upstream raw materials:

succinic acid anhydride

glycine

C₁₃H₁₃NO₄

succinic acid

Downstream raw materials:

1-{2-[4-(2-chlorophenyl)piperazin-1-yl]-2-oxoethyl}pyrrolidine-2,5-dione

1-{2-[4-(4-chlorophenyl)piperazin-1-yl]-2-oxoethyl}pyrrolidine-2,5-dione

1-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl}pyrrolidine-2,5-dione

1-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}pyrrolidine-2,5-dione