4-Hydroxy-3-Methoxy-1-Methylquinolin-2(1H)-one

Base Information

• Chemical Name: 4-Hydroxy-3-Methoxy-1-Methylquinolin-2(1H)-one
• CAS No.: 90061-39-5
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.21000
• Hs Code.: 2933790090
• Mol file: 90061-39-5.mol

Synonyms:4-hydroxy-3-methoxy-1-methyl-1H-quinolin-2-one;4-Hydroxy-3-methoxy-1-methyl-1H-chinolin-2-on;

Chemical Property of 4-Hydroxy-3-Methoxy-1-Methylquinolin-2(1H)-one

Chemical Property:

• PSA: 51.46000
• LogP: 1.25270
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

4-hydroxy-3-methoxy-1-methylquinolin-2(1H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-3-Methoxy-1-Methylquinolin-2(1H)-one

There total 4 articles about 4-Hydroxy-3-Methoxy-1-Methylquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 1-methyl-3-(phenyl-λ3-iodanylidene)quinoline-2,4(1H,3H)-dione (68903-69-5) → 3,4-Dihydroxy-1-methyl-chinolin-2(1H)-on (41878-54-0) + 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (90061-39-5)

Guidance literature:

With dimethyl sulfate; for 24h;

DOI:10.1007/BF00798414

Reference yield:

2,3-dimethoxy-1-methyl-1H-quinolin-4-one (860715-02-2) → 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (90061-39-5)

Guidance literature:

With hydrogenchloride;

Reference yield:

ethyl 2-methoxyacetate (3938-96-3) + N-Methylisatoic anhydride (10328-92-4) → 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (90061-39-5)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, -78 deg C, 1 h; 2) -78 deg C, 10 min.;

DOI:10.1002/jhet.5570220432

upstream raw materials:

2,3-dimethoxy-1-methyl-1H-quinolin-4-one

methanol

1-methyl-3-(phenyl-λ³-iodanylidene)quinoline-2,4(1H,3H)-dione

ethyl 2-methoxyacetate